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Portal Hypertension as Immune Mediate Disease
CONTEXT: Portal Hypertension (PH) is a progressive complication due to chronic liver disease. In addition to pathophysiologic changes in the micro-circulation, in PH are established fibrous tissue (periportal fibrous septal) and regenerative hyperplastic nodules (from micro- to macro-nodules) promot...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071352/ https://www.ncbi.nlm.nih.gov/pubmed/24976841 http://dx.doi.org/10.5812/hepatmon.18625 |
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author | Manti, Sara Marseglia, Lucia D'Angelo, Gabriella Filippelli, Martina Cuppari, Caterina Gitto, Eloisa Romano, Claudio Arrigo, Teresa Salpietro, Carmelo |
author_facet | Manti, Sara Marseglia, Lucia D'Angelo, Gabriella Filippelli, Martina Cuppari, Caterina Gitto, Eloisa Romano, Claudio Arrigo, Teresa Salpietro, Carmelo |
author_sort | Manti, Sara |
collection | PubMed |
description | CONTEXT: Portal Hypertension (PH) is a progressive complication due to chronic liver disease. In addition to pathophysiologic changes in the micro-circulation, in PH are established fibrous tissue (periportal fibrous septal) and regenerative hyperplastic nodules (from micro- to macro-nodules) promoting hepatic architectural distortion. EVIDENCE ACQUISITION: A literature search of electronic databases was undertaken for the major studies published from 1981 to today. The databases searched were: PubMed, EMBASE, Orphanet, Midline and Cochrane Library. We used the keywords: "portal hypertension, children, immune system, endocrine system, liver fibrosis". RESULTS: It is believed that PH results from three “phenotype”: ischemia-reperfusion, involving nervous system (NS); edema and oxidative damage, involving immune system; inflammation and angiogenesis, involving endocrine system. However, its exact cause still underdiagnosed and unknown. CONCLUSIONS: PH is a dynamic and potentially reversible process. Researchers have tried to demonstrate mechanisms underlying PH and its related-complications. This review focuses on the current knowledge regarding the pathogenesis, and immune, endocrine-metabolic factors of disease. The strong positive association between immune system and development of PH could be efficient to identify non-invasive markers of disease, to modify prognosis of PH, and to development and application of specific and individual anti-inflammatory therapy. |
format | Online Article Text |
id | pubmed-4071352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-40713522014-06-27 Portal Hypertension as Immune Mediate Disease Manti, Sara Marseglia, Lucia D'Angelo, Gabriella Filippelli, Martina Cuppari, Caterina Gitto, Eloisa Romano, Claudio Arrigo, Teresa Salpietro, Carmelo Hepat Mon Review Article CONTEXT: Portal Hypertension (PH) is a progressive complication due to chronic liver disease. In addition to pathophysiologic changes in the micro-circulation, in PH are established fibrous tissue (periportal fibrous septal) and regenerative hyperplastic nodules (from micro- to macro-nodules) promoting hepatic architectural distortion. EVIDENCE ACQUISITION: A literature search of electronic databases was undertaken for the major studies published from 1981 to today. The databases searched were: PubMed, EMBASE, Orphanet, Midline and Cochrane Library. We used the keywords: "portal hypertension, children, immune system, endocrine system, liver fibrosis". RESULTS: It is believed that PH results from three “phenotype”: ischemia-reperfusion, involving nervous system (NS); edema and oxidative damage, involving immune system; inflammation and angiogenesis, involving endocrine system. However, its exact cause still underdiagnosed and unknown. CONCLUSIONS: PH is a dynamic and potentially reversible process. Researchers have tried to demonstrate mechanisms underlying PH and its related-complications. This review focuses on the current knowledge regarding the pathogenesis, and immune, endocrine-metabolic factors of disease. The strong positive association between immune system and development of PH could be efficient to identify non-invasive markers of disease, to modify prognosis of PH, and to development and application of specific and individual anti-inflammatory therapy. Kowsar 2014-06-07 /pmc/articles/PMC4071352/ /pubmed/24976841 http://dx.doi.org/10.5812/hepatmon.18625 Text en Copyright © 2014, Kowsar Corp.; Published by Kowsar Corp. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Manti, Sara Marseglia, Lucia D'Angelo, Gabriella Filippelli, Martina Cuppari, Caterina Gitto, Eloisa Romano, Claudio Arrigo, Teresa Salpietro, Carmelo Portal Hypertension as Immune Mediate Disease |
title | Portal Hypertension as Immune Mediate Disease |
title_full | Portal Hypertension as Immune Mediate Disease |
title_fullStr | Portal Hypertension as Immune Mediate Disease |
title_full_unstemmed | Portal Hypertension as Immune Mediate Disease |
title_short | Portal Hypertension as Immune Mediate Disease |
title_sort | portal hypertension as immune mediate disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071352/ https://www.ncbi.nlm.nih.gov/pubmed/24976841 http://dx.doi.org/10.5812/hepatmon.18625 |
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