The role of the cytoskeleton and molecular motors in endosomal dynamics

The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins...

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Detalles Bibliográficos
Autores principales: Granger, Elizabeth, McNee, Gavin, Allan, Victoria, Woodman, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071412/
https://www.ncbi.nlm.nih.gov/pubmed/24727350
http://dx.doi.org/10.1016/j.semcdb.2014.04.011
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author Granger, Elizabeth
McNee, Gavin
Allan, Victoria
Woodman, Philip
author_facet Granger, Elizabeth
McNee, Gavin
Allan, Victoria
Woodman, Philip
author_sort Granger, Elizabeth
collection PubMed
description The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.
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spelling pubmed-40714122014-07-07 The role of the cytoskeleton and molecular motors in endosomal dynamics Granger, Elizabeth McNee, Gavin Allan, Victoria Woodman, Philip Semin Cell Dev Biol Review The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates. Academic Press 2014-07 /pmc/articles/PMC4071412/ /pubmed/24727350 http://dx.doi.org/10.1016/j.semcdb.2014.04.011 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Granger, Elizabeth
McNee, Gavin
Allan, Victoria
Woodman, Philip
The role of the cytoskeleton and molecular motors in endosomal dynamics
title The role of the cytoskeleton and molecular motors in endosomal dynamics
title_full The role of the cytoskeleton and molecular motors in endosomal dynamics
title_fullStr The role of the cytoskeleton and molecular motors in endosomal dynamics
title_full_unstemmed The role of the cytoskeleton and molecular motors in endosomal dynamics
title_short The role of the cytoskeleton and molecular motors in endosomal dynamics
title_sort role of the cytoskeleton and molecular motors in endosomal dynamics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071412/
https://www.ncbi.nlm.nih.gov/pubmed/24727350
http://dx.doi.org/10.1016/j.semcdb.2014.04.011
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