New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

Four new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determine...

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Detalles Bibliográficos
Autores principales: Fredimoses, Mangaladoss, Zhou, Xuefeng, Lin, Xiuping, Tian, Xinpeng, Ai, Wen, Wang, Junfeng, Liao, Shengrong, Liu, Juan, Yang, Bin, Yang, Xianwen, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071571/
https://www.ncbi.nlm.nih.gov/pubmed/24879543
http://dx.doi.org/10.3390/md12063190
Descripción
Sumario:Four new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR ((1)H, (13)C NMR, HSQC, HMBC, and (1)H-(1)H COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1 and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens.

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