Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa

Four new cembrane-type diterpenes; numerosol A–D (1–4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited...

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Detalles Bibliográficos
Autores principales: Tseng, Yen-Ju, Yang, Yuan-Chien, Wang, Shang-Kwei, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071581/
https://www.ncbi.nlm.nih.gov/pubmed/24897385
http://dx.doi.org/10.3390/md12063371
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author Tseng, Yen-Ju
Yang, Yuan-Chien
Wang, Shang-Kwei
Duh, Chang-Yih
author_facet Tseng, Yen-Ju
Yang, Yuan-Chien
Wang, Shang-Kwei
Duh, Chang-Yih
author_sort Tseng, Yen-Ju
collection PubMed
description Four new cembrane-type diterpenes; numerosol A–D (1–4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED(50) of 6.9 μM.
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spelling pubmed-40715812014-06-26 Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa Tseng, Yen-Ju Yang, Yuan-Chien Wang, Shang-Kwei Duh, Chang-Yih Mar Drugs Article Four new cembrane-type diterpenes; numerosol A–D (1–4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED(50) of 6.9 μM. MDPI 2014-06-03 /pmc/articles/PMC4071581/ /pubmed/24897385 http://dx.doi.org/10.3390/md12063371 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tseng, Yen-Ju
Yang, Yuan-Chien
Wang, Shang-Kwei
Duh, Chang-Yih
Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa
title Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa
title_full Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa
title_fullStr Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa
title_full_unstemmed Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa
title_short Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa
title_sort numerosol a–d, new cembranoid diterpenes from the soft coral sinularia numerosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071581/
https://www.ncbi.nlm.nih.gov/pubmed/24897385
http://dx.doi.org/10.3390/md12063371
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