Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata

Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and between C-20 and C-11. Their structures were elucidated...

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Autores principales: Lin, Yu-Chi, Wang, Shih-Sheng, Chen, Chung-Hsiung, Kuo, Yao-Haur, Shen, Ya-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071587/
https://www.ncbi.nlm.nih.gov/pubmed/24905485
http://dx.doi.org/10.3390/md12063477
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author Lin, Yu-Chi
Wang, Shih-Sheng
Chen, Chung-Hsiung
Kuo, Yao-Haur
Shen, Ya-Ching
author_facet Lin, Yu-Chi
Wang, Shih-Sheng
Chen, Chung-Hsiung
Kuo, Yao-Haur
Shen, Ya-Ching
author_sort Lin, Yu-Chi
collection PubMed
description Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and between C-20 and C-11. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 1 exhibited significant cytotoxicity against human medulloblastoma and colon adenocarcinoma cancer cells.
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spelling pubmed-40715872014-06-26 Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata Lin, Yu-Chi Wang, Shih-Sheng Chen, Chung-Hsiung Kuo, Yao-Haur Shen, Ya-Ching Mar Drugs Communication Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and between C-20 and C-11. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 1 exhibited significant cytotoxicity against human medulloblastoma and colon adenocarcinoma cancer cells. MDPI 2014-06-05 /pmc/articles/PMC4071587/ /pubmed/24905485 http://dx.doi.org/10.3390/md12063477 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Lin, Yu-Chi
Wang, Shih-Sheng
Chen, Chung-Hsiung
Kuo, Yao-Haur
Shen, Ya-Ching
Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata
title Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata
title_full Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata
title_fullStr Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata
title_full_unstemmed Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata
title_short Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata
title_sort cespitulones a and b, cytotoxic diterpenoids of a new structure class from the soft coral cespitularia taeniata
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071587/
https://www.ncbi.nlm.nih.gov/pubmed/24905485
http://dx.doi.org/10.3390/md12063477
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