Amino Alcohols from the Ascidian Pseudodistoma sp

Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxy...

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Detalles Bibliográficos
Autores principales: Won, Tae Hyung, You, Minjung, Lee, So-Hyoung, Rho, Boon Jo, Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071600/
https://www.ncbi.nlm.nih.gov/pubmed/24962272
http://dx.doi.org/10.3390/md12063754
Descripción
Sumario:Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na(+)/K(+)-ATPase.

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