Amino Alcohols from the Ascidian Pseudodistoma sp

Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxy...

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Autores principales: Won, Tae Hyung, You, Minjung, Lee, So-Hyoung, Rho, Boon Jo, Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071600/
https://www.ncbi.nlm.nih.gov/pubmed/24962272
http://dx.doi.org/10.3390/md12063754
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author Won, Tae Hyung
You, Minjung
Lee, So-Hyoung
Rho, Boon Jo
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
author_facet Won, Tae Hyung
You, Minjung
Lee, So-Hyoung
Rho, Boon Jo
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
author_sort Won, Tae Hyung
collection PubMed
description Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na(+)/K(+)-ATPase.
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spelling pubmed-40716002014-06-26 Amino Alcohols from the Ascidian Pseudodistoma sp Won, Tae Hyung You, Minjung Lee, So-Hyoung Rho, Boon Jo Oh, Dong-Chan Oh, Ki-Bong Shin, Jongheon Mar Drugs Article Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na(+)/K(+)-ATPase. MDPI 2014-06-24 /pmc/articles/PMC4071600/ /pubmed/24962272 http://dx.doi.org/10.3390/md12063754 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Won, Tae Hyung
You, Minjung
Lee, So-Hyoung
Rho, Boon Jo
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
Amino Alcohols from the Ascidian Pseudodistoma sp
title Amino Alcohols from the Ascidian Pseudodistoma sp
title_full Amino Alcohols from the Ascidian Pseudodistoma sp
title_fullStr Amino Alcohols from the Ascidian Pseudodistoma sp
title_full_unstemmed Amino Alcohols from the Ascidian Pseudodistoma sp
title_short Amino Alcohols from the Ascidian Pseudodistoma sp
title_sort amino alcohols from the ascidian pseudodistoma sp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071600/
https://www.ncbi.nlm.nih.gov/pubmed/24962272
http://dx.doi.org/10.3390/md12063754
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