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Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats

OBJECTIVES: The present study was designed to evaluate the ameliorative effect of Elaeocarpus ganitrus on gentamicin (GM)-induced nephrotoxicity in rats. MATERIALS AND METHODS: E. ganitrus (100, 200, and 400 mg/kg body weight) was administered orally to male Wistar rats. GM (100 mg/kg) was used to i...

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Autores principales: Kakalij, Rahul Motiram, Alla, Chaitanya P., Kshirsagar, Rahul P., Kumar, Boyina Hemanth, Mutha, Sumeet S., Diwan, Prakash Vamanrao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071707/
https://www.ncbi.nlm.nih.gov/pubmed/24987177
http://dx.doi.org/10.4103/0253-7613.132163
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author Kakalij, Rahul Motiram
Alla, Chaitanya P.
Kshirsagar, Rahul P.
Kumar, Boyina Hemanth
Mutha, Sumeet S.
Diwan, Prakash Vamanrao
author_facet Kakalij, Rahul Motiram
Alla, Chaitanya P.
Kshirsagar, Rahul P.
Kumar, Boyina Hemanth
Mutha, Sumeet S.
Diwan, Prakash Vamanrao
author_sort Kakalij, Rahul Motiram
collection PubMed
description OBJECTIVES: The present study was designed to evaluate the ameliorative effect of Elaeocarpus ganitrus on gentamicin (GM)-induced nephrotoxicity in rats. MATERIALS AND METHODS: E. ganitrus (100, 200, and 400 mg/kg body weight) was administered orally to male Wistar rats. GM (100 mg/kg) was used to induce nephrotoxicity. Study parameters include serum albumin, creatinine, blood urea nitrogen (BUN), uric acid, creatinine, and albuminuria. Total protein in serum, antioxidant enzymes activities, phagocytic index, and neutrophil adhesion assays were performed to determine oxidative stress and immunomodulatory action of E. ganitrus. RESULTS: The results revealed that coadministration of E. ganitrus significantly reduced the elevated level of serum creatinine, BUN, uric acid, and albuminuria with considerable increase in the serum albumin and urine creatinine. Furthermore, E. ganitrus noticeably increased serum total protein and antioxidant enzyme levels with significant alteration in phagocytic index and neutrophil adhesion assay when compared with GM-treated group in a dose-dependent manner. CONCLUSION: The present study revealed that ethanolic extract of E. ganitrus seeds has immunomodulatory and nephroprotective activity.
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spelling pubmed-40717072014-07-01 Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats Kakalij, Rahul Motiram Alla, Chaitanya P. Kshirsagar, Rahul P. Kumar, Boyina Hemanth Mutha, Sumeet S. Diwan, Prakash Vamanrao Indian J Pharmacol Research Article OBJECTIVES: The present study was designed to evaluate the ameliorative effect of Elaeocarpus ganitrus on gentamicin (GM)-induced nephrotoxicity in rats. MATERIALS AND METHODS: E. ganitrus (100, 200, and 400 mg/kg body weight) was administered orally to male Wistar rats. GM (100 mg/kg) was used to induce nephrotoxicity. Study parameters include serum albumin, creatinine, blood urea nitrogen (BUN), uric acid, creatinine, and albuminuria. Total protein in serum, antioxidant enzymes activities, phagocytic index, and neutrophil adhesion assays were performed to determine oxidative stress and immunomodulatory action of E. ganitrus. RESULTS: The results revealed that coadministration of E. ganitrus significantly reduced the elevated level of serum creatinine, BUN, uric acid, and albuminuria with considerable increase in the serum albumin and urine creatinine. Furthermore, E. ganitrus noticeably increased serum total protein and antioxidant enzyme levels with significant alteration in phagocytic index and neutrophil adhesion assay when compared with GM-treated group in a dose-dependent manner. CONCLUSION: The present study revealed that ethanolic extract of E. ganitrus seeds has immunomodulatory and nephroprotective activity. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4071707/ /pubmed/24987177 http://dx.doi.org/10.4103/0253-7613.132163 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kakalij, Rahul Motiram
Alla, Chaitanya P.
Kshirsagar, Rahul P.
Kumar, Boyina Hemanth
Mutha, Sumeet S.
Diwan, Prakash Vamanrao
Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats
title Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats
title_full Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats
title_fullStr Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats
title_full_unstemmed Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats
title_short Ameliorative effect of Elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats
title_sort ameliorative effect of elaeocarpus ganitrus on gentamicin-induced nephrotoxicity in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071707/
https://www.ncbi.nlm.nih.gov/pubmed/24987177
http://dx.doi.org/10.4103/0253-7613.132163
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