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A Study on Assessment of Mast Cells in Oral Squamous Cell Carcinoma

BACKGROUND: Apart from the role of mast cells in maintenance of homeostasis and inflammation, their association with tumors has been described recently. In several malignancies, mast cell density has been found to correlate with angiogenesis, increased risk of metastasis and poor prognosis. AIM: The...

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Autores principales: Zaidi, MA, Mallick, AK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071751/
https://www.ncbi.nlm.nih.gov/pubmed/24971226
http://dx.doi.org/10.4103/2141-9248.133479
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author Zaidi, MA
Mallick, AK
author_facet Zaidi, MA
Mallick, AK
author_sort Zaidi, MA
collection PubMed
description BACKGROUND: Apart from the role of mast cells in maintenance of homeostasis and inflammation, their association with tumors has been described recently. In several malignancies, mast cell density has been found to correlate with angiogenesis, increased risk of metastasis and poor prognosis. AIM: The aim of the following study is to compare the number, topography and distribution of mast cells between normal oral mucosa and oral oral squamous cell carcinoma (SCC) and study the significance of mast cells in development of oral SCC. SUBJECTS AND METHODS: A prospective case-control study including 100 patients was conducted after obtaining informed consent and ethical committee clearance. Forty cases were normal controls and 60 cases had oral SCC. Biopsy was performed and both qualitative and quantitative study of mast cells was done. Statistical analysis was carried out using Statistical Package for Social Sciences (SPSS) 17.0 version (SPSS Inc., Chicago, IL, USA). RESULTS: Buccal/labial mucosa was the most common site of lesion in SCC. Total mast cells count was a higher in SCC when compared with controls, which was a statistically significant (P < 0.001). SCC had significantly (P < 0.001) higher levels of degranulated mast cell. CONCLUSION: Role of mast cells in tumors may have direct clinical relevance and consequently, important clinical implications. Mast cells serves as a novel therapeutic target for cancer treatment and that inhibiting mast cell function may inhibit tumor growth.
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spelling pubmed-40717512014-06-26 A Study on Assessment of Mast Cells in Oral Squamous Cell Carcinoma Zaidi, MA Mallick, AK Ann Med Health Sci Res Original Article BACKGROUND: Apart from the role of mast cells in maintenance of homeostasis and inflammation, their association with tumors has been described recently. In several malignancies, mast cell density has been found to correlate with angiogenesis, increased risk of metastasis and poor prognosis. AIM: The aim of the following study is to compare the number, topography and distribution of mast cells between normal oral mucosa and oral oral squamous cell carcinoma (SCC) and study the significance of mast cells in development of oral SCC. SUBJECTS AND METHODS: A prospective case-control study including 100 patients was conducted after obtaining informed consent and ethical committee clearance. Forty cases were normal controls and 60 cases had oral SCC. Biopsy was performed and both qualitative and quantitative study of mast cells was done. Statistical analysis was carried out using Statistical Package for Social Sciences (SPSS) 17.0 version (SPSS Inc., Chicago, IL, USA). RESULTS: Buccal/labial mucosa was the most common site of lesion in SCC. Total mast cells count was a higher in SCC when compared with controls, which was a statistically significant (P < 0.001). SCC had significantly (P < 0.001) higher levels of degranulated mast cell. CONCLUSION: Role of mast cells in tumors may have direct clinical relevance and consequently, important clinical implications. Mast cells serves as a novel therapeutic target for cancer treatment and that inhibiting mast cell function may inhibit tumor growth. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4071751/ /pubmed/24971226 http://dx.doi.org/10.4103/2141-9248.133479 Text en Copyright: © Annals of Medical and Health Sciences Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zaidi, MA
Mallick, AK
A Study on Assessment of Mast Cells in Oral Squamous Cell Carcinoma
title A Study on Assessment of Mast Cells in Oral Squamous Cell Carcinoma
title_full A Study on Assessment of Mast Cells in Oral Squamous Cell Carcinoma
title_fullStr A Study on Assessment of Mast Cells in Oral Squamous Cell Carcinoma
title_full_unstemmed A Study on Assessment of Mast Cells in Oral Squamous Cell Carcinoma
title_short A Study on Assessment of Mast Cells in Oral Squamous Cell Carcinoma
title_sort study on assessment of mast cells in oral squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071751/
https://www.ncbi.nlm.nih.gov/pubmed/24971226
http://dx.doi.org/10.4103/2141-9248.133479
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