The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring

We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21...

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Detalles Bibliográficos
Autores principales: Wang, Lingxing, Li, Meimei, Huang, Ziyang, Wang, Zhenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071786/
https://www.ncbi.nlm.nih.gov/pubmed/25013780
http://dx.doi.org/10.1155/2014/419805
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author Wang, Lingxing
Li, Meimei
Huang, Ziyang
Wang, Zhenhua
author_facet Wang, Lingxing
Li, Meimei
Huang, Ziyang
Wang, Zhenhua
author_sort Wang, Lingxing
collection PubMed
description We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P < 0.05). Maternal hypoxia from day 15 to 21 of pregnancy had no effect on adult collagen levels. Our results indicate that maternal hypoxia at critical windows of cardiovascular development can induce pathological cardiac remodeling in the adult rat offspring.
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spelling pubmed-40717862014-07-10 The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring Wang, Lingxing Li, Meimei Huang, Ziyang Wang, Zhenhua Biomed Res Int Research Article We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P < 0.05). Maternal hypoxia from day 15 to 21 of pregnancy had no effect on adult collagen levels. Our results indicate that maternal hypoxia at critical windows of cardiovascular development can induce pathological cardiac remodeling in the adult rat offspring. Hindawi Publishing Corporation 2014 2014-06-11 /pmc/articles/PMC4071786/ /pubmed/25013780 http://dx.doi.org/10.1155/2014/419805 Text en Copyright © 2014 Lingxing Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Lingxing
Li, Meimei
Huang, Ziyang
Wang, Zhenhua
The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring
title The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring
title_full The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring
title_fullStr The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring
title_full_unstemmed The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring
title_short The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring
title_sort influence of hypoxia during different pregnancy stages on cardiac collagen accumulation in the adult offspring
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071786/
https://www.ncbi.nlm.nih.gov/pubmed/25013780
http://dx.doi.org/10.1155/2014/419805
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