Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)

Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P < 0.014–0.0006) up...

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Autores principales: Cockeran, Riana, Herbert, Jenny A., Mitchell, Timothy J., Dix-Peek, Thérèse, Dickens, Caroline, Anderson, Ronald, Feldman, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071851/
https://www.ncbi.nlm.nih.gov/pubmed/25013815
http://dx.doi.org/10.1155/2014/976347
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author Cockeran, Riana
Herbert, Jenny A.
Mitchell, Timothy J.
Dix-Peek, Thérèse
Dickens, Caroline
Anderson, Ronald
Feldman, Charles
author_facet Cockeran, Riana
Herbert, Jenny A.
Mitchell, Timothy J.
Dix-Peek, Thérèse
Dickens, Caroline
Anderson, Ronald
Feldman, Charles
author_sort Cockeran, Riana
collection PubMed
description Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P < 0.014–0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.
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spelling pubmed-40718512014-07-10 Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11) Cockeran, Riana Herbert, Jenny A. Mitchell, Timothy J. Dix-Peek, Thérèse Dickens, Caroline Anderson, Ronald Feldman, Charles Biomed Res Int Research Article Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P < 0.014–0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen. Hindawi Publishing Corporation 2014 2014-06-11 /pmc/articles/PMC4071851/ /pubmed/25013815 http://dx.doi.org/10.1155/2014/976347 Text en Copyright © 2014 Riana Cockeran et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cockeran, Riana
Herbert, Jenny A.
Mitchell, Timothy J.
Dix-Peek, Thérèse
Dickens, Caroline
Anderson, Ronald
Feldman, Charles
Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)
title Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)
title_full Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)
title_fullStr Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)
title_full_unstemmed Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)
title_short Exposure of a 23F Serotype Strain of Streptococcus pneumoniae to Cigarette Smoke Condensate Is Associated with Selective Upregulation of Genes Encoding the Two-Component Regulatory System 11 (TCS11)
title_sort exposure of a 23f serotype strain of streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (tcs11)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071851/
https://www.ncbi.nlm.nih.gov/pubmed/25013815
http://dx.doi.org/10.1155/2014/976347
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