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TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development
The transforming growth factor-β (TGF-β) superfamily is a family of structurally related proteins that includes TGF-β, activins/inhibins, and bone morphogenic proteins (BMPs). Members of the TGF-β superfamily regulate cellular functions such as proliferation, apoptosis, differentiation, and migratio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071855/ https://www.ncbi.nlm.nih.gov/pubmed/25110717 http://dx.doi.org/10.1155/2014/318481 |
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author | Tirado-Rodriguez, Belen Ortega, Enrique Segura-Medina, Patricia Huerta-Yepez, Sara |
author_facet | Tirado-Rodriguez, Belen Ortega, Enrique Segura-Medina, Patricia Huerta-Yepez, Sara |
author_sort | Tirado-Rodriguez, Belen |
collection | PubMed |
description | The transforming growth factor-β (TGF-β) superfamily is a family of structurally related proteins that includes TGF-β, activins/inhibins, and bone morphogenic proteins (BMPs). Members of the TGF-β superfamily regulate cellular functions such as proliferation, apoptosis, differentiation, and migration and thus play key roles in organismal development. TGF-β is involved in several human diseases, including autoimmune disorders and vascular diseases. Activation of the TGF-β receptor induces phosphorylation of serine/threonine residues and triggers phosphorylation of intracellular effectors (Smads). Once activated, Smad proteins translocate to the nucleus and induce transcription of their target genes, regulating various processes and cellular functions. Recently, there has been an attempt to correlate the effect of TGF-β with various pathological entities such as allergic diseases and cancer, yielding a new area of research known as “allergooncology," which investigates the mechanisms by which allergic diseases may influence the progression of certain cancers. This knowledge could generate new therapeutic strategies aimed at correcting the pathologies in which TGF-β is involved. Here, we review recent studies that suggest an important role for TGF-β in both allergic disease and cancer progression. |
format | Online Article Text |
id | pubmed-4071855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40718552014-08-10 TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development Tirado-Rodriguez, Belen Ortega, Enrique Segura-Medina, Patricia Huerta-Yepez, Sara J Immunol Res Review Article The transforming growth factor-β (TGF-β) superfamily is a family of structurally related proteins that includes TGF-β, activins/inhibins, and bone morphogenic proteins (BMPs). Members of the TGF-β superfamily regulate cellular functions such as proliferation, apoptosis, differentiation, and migration and thus play key roles in organismal development. TGF-β is involved in several human diseases, including autoimmune disorders and vascular diseases. Activation of the TGF-β receptor induces phosphorylation of serine/threonine residues and triggers phosphorylation of intracellular effectors (Smads). Once activated, Smad proteins translocate to the nucleus and induce transcription of their target genes, regulating various processes and cellular functions. Recently, there has been an attempt to correlate the effect of TGF-β with various pathological entities such as allergic diseases and cancer, yielding a new area of research known as “allergooncology," which investigates the mechanisms by which allergic diseases may influence the progression of certain cancers. This knowledge could generate new therapeutic strategies aimed at correcting the pathologies in which TGF-β is involved. Here, we review recent studies that suggest an important role for TGF-β in both allergic disease and cancer progression. Hindawi Publishing Corporation 2014 2014-06-11 /pmc/articles/PMC4071855/ /pubmed/25110717 http://dx.doi.org/10.1155/2014/318481 Text en Copyright © 2014 Belen Tirado-Rodriguez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tirado-Rodriguez, Belen Ortega, Enrique Segura-Medina, Patricia Huerta-Yepez, Sara TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development |
title | TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development |
title_full | TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development |
title_fullStr | TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development |
title_full_unstemmed | TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development |
title_short | TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development |
title_sort | tgf-β: an important mediator of allergic disease and a molecule with dual activity in cancer development |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071855/ https://www.ncbi.nlm.nih.gov/pubmed/25110717 http://dx.doi.org/10.1155/2014/318481 |
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