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Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design
The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 3(2) full factorial design was employ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071986/ https://www.ncbi.nlm.nih.gov/pubmed/25006462 http://dx.doi.org/10.1155/2014/305863 |
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author | Gajra, Balaram Pandya, Saurabh S. Singh, Sanjay Rabari, Haribhai A. |
author_facet | Gajra, Balaram Pandya, Saurabh S. Singh, Sanjay Rabari, Haribhai A. |
author_sort | Gajra, Balaram |
collection | PubMed |
description | The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 3(2) full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concentration of the poly(vinyl alcohol) (10, 15, and 20%) were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and “k” of zero order equation were used as the dependent variables. The films were evaluated for mucoadhesive strength, in vitro residence time, swelling study, in vitro drug release, and effectiveness against Candida albicans. The concentration of poly(vinyl alcohol) and the number of freeze/thaw cycles both decrease the drug release rate. Mucoadhesive hydrogel film with 15% poly(vinyl alcohol) and 7 freeze/thaw cycles was optimized. The optimized batch exhibited the sustained release of drug and the antifungal studies revealed that the drug released from the film could inhibit the growth of Candida albicans for 12 hours. |
format | Online Article Text |
id | pubmed-4071986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40719862014-07-08 Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design Gajra, Balaram Pandya, Saurabh S. Singh, Sanjay Rabari, Haribhai A. J Drug Deliv Research Article The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 3(2) full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concentration of the poly(vinyl alcohol) (10, 15, and 20%) were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and “k” of zero order equation were used as the dependent variables. The films were evaluated for mucoadhesive strength, in vitro residence time, swelling study, in vitro drug release, and effectiveness against Candida albicans. The concentration of poly(vinyl alcohol) and the number of freeze/thaw cycles both decrease the drug release rate. Mucoadhesive hydrogel film with 15% poly(vinyl alcohol) and 7 freeze/thaw cycles was optimized. The optimized batch exhibited the sustained release of drug and the antifungal studies revealed that the drug released from the film could inhibit the growth of Candida albicans for 12 hours. Hindawi Publishing Corporation 2014 2014-06-10 /pmc/articles/PMC4071986/ /pubmed/25006462 http://dx.doi.org/10.1155/2014/305863 Text en Copyright © 2014 Balaram Gajra et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gajra, Balaram Pandya, Saurabh S. Singh, Sanjay Rabari, Haribhai A. Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design |
title | Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design |
title_full | Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design |
title_fullStr | Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design |
title_full_unstemmed | Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design |
title_short | Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design |
title_sort | mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071986/ https://www.ncbi.nlm.nih.gov/pubmed/25006462 http://dx.doi.org/10.1155/2014/305863 |
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