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No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy
OBJECTIVE: Β(2)-microglobulin (β(2)M) associated amyloidosis is an inevitable complication of chronic kidney disease (CKD). Testing β(2)M in the blood is invasive and expensive. On the other hand, oral fluid is a perfect medium to be explored for public health and disease surveillance. However, it h...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072078/ https://www.ncbi.nlm.nih.gov/pubmed/24567934 |
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author | Assareh, Ahmadreza Assareh Haybar, Habib Malekzadeh, Hosein Yazdanpanah, Leila Bozorgmanesh, Mohammadreza |
author_facet | Assareh, Ahmadreza Assareh Haybar, Habib Malekzadeh, Hosein Yazdanpanah, Leila Bozorgmanesh, Mohammadreza |
author_sort | Assareh, Ahmadreza Assareh |
collection | PubMed |
description | OBJECTIVE: Β(2)-microglobulin (β(2)M) associated amyloidosis is an inevitable complication of chronic kidney disease (CKD). Testing β(2)M in the blood is invasive and expensive. On the other hand, oral fluid is a perfect medium to be explored for public health and disease surveillance. However, it has never been studied if salivary concentration of β(2)M reflects its concentration in the serum. The current study; therefore, aimed to examine the relationship between salivary and serum β(2)M in a sample of adult diabetic men with CKD. MATERIALS AND METHODS: Among diabetic patients referred to the Nephrology Department of The Golestan Hospital of Ahvaz due to CKD, 40 men not requiring renal replacement therapy were consecutively recruited for this cross-sectional study. Patients were excluded if they had any disease or were using any drugs that might affect the oral mucosa or saliva. The concentration of β(2)M was measured in both serum and saliva. The correlation between serum and salivary β(2)M was measured by calculating spearman’s ρ. RESULTS: The Spearman’s ρ for correlation between serum and salivary β(2)M was -0.017 (p=0.917), indicating lack of correlation. Serum and salivary creatinine (Spearman’s ρ=0.54; p value<0.001) as well as serum and salivary urea nitrogen levels (Spearman’s ρ=0.39; p value=0.014) were correlated. CONCLUSION: Salivary β(2)M levels poorly agreed with serum β(2)M levels, and thus may not be used as a surrogate for serum β(2)M in CKD patients who did not require replacement therapy. |
format | Online Article Text |
id | pubmed-4072078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-40720782014-07-09 No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy Assareh, Ahmadreza Assareh Haybar, Habib Malekzadeh, Hosein Yazdanpanah, Leila Bozorgmanesh, Mohammadreza Cell J Original Article OBJECTIVE: Β(2)-microglobulin (β(2)M) associated amyloidosis is an inevitable complication of chronic kidney disease (CKD). Testing β(2)M in the blood is invasive and expensive. On the other hand, oral fluid is a perfect medium to be explored for public health and disease surveillance. However, it has never been studied if salivary concentration of β(2)M reflects its concentration in the serum. The current study; therefore, aimed to examine the relationship between salivary and serum β(2)M in a sample of adult diabetic men with CKD. MATERIALS AND METHODS: Among diabetic patients referred to the Nephrology Department of The Golestan Hospital of Ahvaz due to CKD, 40 men not requiring renal replacement therapy were consecutively recruited for this cross-sectional study. Patients were excluded if they had any disease or were using any drugs that might affect the oral mucosa or saliva. The concentration of β(2)M was measured in both serum and saliva. The correlation between serum and salivary β(2)M was measured by calculating spearman’s ρ. RESULTS: The Spearman’s ρ for correlation between serum and salivary β(2)M was -0.017 (p=0.917), indicating lack of correlation. Serum and salivary creatinine (Spearman’s ρ=0.54; p value<0.001) as well as serum and salivary urea nitrogen levels (Spearman’s ρ=0.39; p value=0.014) were correlated. CONCLUSION: Salivary β(2)M levels poorly agreed with serum β(2)M levels, and thus may not be used as a surrogate for serum β(2)M in CKD patients who did not require replacement therapy. Royan Institute 2014 2014-05-25 /pmc/articles/PMC4072078/ /pubmed/24567934 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Assareh, Ahmadreza Assareh Haybar, Habib Malekzadeh, Hosein Yazdanpanah, Leila Bozorgmanesh, Mohammadreza No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy |
title | No Relationship between Serum and Salivary β(2)-
Microglobulin Levels in A Sample of Adult Diabetic
Men with Chronic Kidney Disease without Renal
Replacement Therapy |
title_full | No Relationship between Serum and Salivary β(2)-
Microglobulin Levels in A Sample of Adult Diabetic
Men with Chronic Kidney Disease without Renal
Replacement Therapy |
title_fullStr | No Relationship between Serum and Salivary β(2)-
Microglobulin Levels in A Sample of Adult Diabetic
Men with Chronic Kidney Disease without Renal
Replacement Therapy |
title_full_unstemmed | No Relationship between Serum and Salivary β(2)-
Microglobulin Levels in A Sample of Adult Diabetic
Men with Chronic Kidney Disease without Renal
Replacement Therapy |
title_short | No Relationship between Serum and Salivary β(2)-
Microglobulin Levels in A Sample of Adult Diabetic
Men with Chronic Kidney Disease without Renal
Replacement Therapy |
title_sort | no relationship between serum and salivary β(2)-
microglobulin levels in a sample of adult diabetic
men with chronic kidney disease without renal
replacement therapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072078/ https://www.ncbi.nlm.nih.gov/pubmed/24567934 |
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