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No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy

OBJECTIVE: Β(2)-microglobulin (β(2)M) associated amyloidosis is an inevitable complication of chronic kidney disease (CKD). Testing β(2)M in the blood is invasive and expensive. On the other hand, oral fluid is a perfect medium to be explored for public health and disease surveillance. However, it h...

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Autores principales: Assareh, Ahmadreza Assareh, Haybar, Habib, Malekzadeh, Hosein, Yazdanpanah, Leila, Bozorgmanesh, Mohammadreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072078/
https://www.ncbi.nlm.nih.gov/pubmed/24567934
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author Assareh, Ahmadreza Assareh
Haybar, Habib
Malekzadeh, Hosein
Yazdanpanah, Leila
Bozorgmanesh, Mohammadreza
author_facet Assareh, Ahmadreza Assareh
Haybar, Habib
Malekzadeh, Hosein
Yazdanpanah, Leila
Bozorgmanesh, Mohammadreza
author_sort Assareh, Ahmadreza Assareh
collection PubMed
description OBJECTIVE: Β(2)-microglobulin (β(2)M) associated amyloidosis is an inevitable complication of chronic kidney disease (CKD). Testing β(2)M in the blood is invasive and expensive. On the other hand, oral fluid is a perfect medium to be explored for public health and disease surveillance. However, it has never been studied if salivary concentration of β(2)M reflects its concentration in the serum. The current study; therefore, aimed to examine the relationship between salivary and serum β(2)M in a sample of adult diabetic men with CKD. MATERIALS AND METHODS: Among diabetic patients referred to the Nephrology Department of The Golestan Hospital of Ahvaz due to CKD, 40 men not requiring renal replacement therapy were consecutively recruited for this cross-sectional study. Patients were excluded if they had any disease or were using any drugs that might affect the oral mucosa or saliva. The concentration of β(2)M was measured in both serum and saliva. The correlation between serum and salivary β(2)M was measured by calculating spearman’s ρ. RESULTS: The Spearman’s ρ for correlation between serum and salivary β(2)M was -0.017 (p=0.917), indicating lack of correlation. Serum and salivary creatinine (Spearman’s ρ=0.54; p value<0.001) as well as serum and salivary urea nitrogen levels (Spearman’s ρ=0.39; p value=0.014) were correlated. CONCLUSION: Salivary β(2)M levels poorly agreed with serum β(2)M levels, and thus may not be used as a surrogate for serum β(2)M in CKD patients who did not require replacement therapy.
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spelling pubmed-40720782014-07-09 No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy Assareh, Ahmadreza Assareh Haybar, Habib Malekzadeh, Hosein Yazdanpanah, Leila Bozorgmanesh, Mohammadreza Cell J Original Article OBJECTIVE: Β(2)-microglobulin (β(2)M) associated amyloidosis is an inevitable complication of chronic kidney disease (CKD). Testing β(2)M in the blood is invasive and expensive. On the other hand, oral fluid is a perfect medium to be explored for public health and disease surveillance. However, it has never been studied if salivary concentration of β(2)M reflects its concentration in the serum. The current study; therefore, aimed to examine the relationship between salivary and serum β(2)M in a sample of adult diabetic men with CKD. MATERIALS AND METHODS: Among diabetic patients referred to the Nephrology Department of The Golestan Hospital of Ahvaz due to CKD, 40 men not requiring renal replacement therapy were consecutively recruited for this cross-sectional study. Patients were excluded if they had any disease or were using any drugs that might affect the oral mucosa or saliva. The concentration of β(2)M was measured in both serum and saliva. The correlation between serum and salivary β(2)M was measured by calculating spearman’s ρ. RESULTS: The Spearman’s ρ for correlation between serum and salivary β(2)M was -0.017 (p=0.917), indicating lack of correlation. Serum and salivary creatinine (Spearman’s ρ=0.54; p value<0.001) as well as serum and salivary urea nitrogen levels (Spearman’s ρ=0.39; p value=0.014) were correlated. CONCLUSION: Salivary β(2)M levels poorly agreed with serum β(2)M levels, and thus may not be used as a surrogate for serum β(2)M in CKD patients who did not require replacement therapy. Royan Institute 2014 2014-05-25 /pmc/articles/PMC4072078/ /pubmed/24567934 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Assareh, Ahmadreza Assareh
Haybar, Habib
Malekzadeh, Hosein
Yazdanpanah, Leila
Bozorgmanesh, Mohammadreza
No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy
title No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy
title_full No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy
title_fullStr No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy
title_full_unstemmed No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy
title_short No Relationship between Serum and Salivary β(2)- Microglobulin Levels in A Sample of Adult Diabetic Men with Chronic Kidney Disease without Renal Replacement Therapy
title_sort no relationship between serum and salivary β(2)- microglobulin levels in a sample of adult diabetic men with chronic kidney disease without renal replacement therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072078/
https://www.ncbi.nlm.nih.gov/pubmed/24567934
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