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Hyaluronan Polymer Length, Grafting Density, and Surface Poly(ethylene glycol) Coating Influence in Vivo Circulation and Tumor Targeting of Hyaluronan-Grafted Liposomes

[Image: see text] Hyaluronan-grafted liposomes (HA-liposomes) preferentially target CD44-overexpressing tumor cells in vitro via receptor-mediated endocytosis. We investigated the pharmacokinetics and biodistribution of HA-liposomes with various sizes of HA (MW 5–8, 50–60, and 175–350 kDa) in mice....

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Detalles Bibliográficos
Autores principales:	Qhattal, Hussaini Syed Sha, Hye, Tanvirul, Alali, Amer, Liu, Xinli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072417/ https://www.ncbi.nlm.nih.gov/pubmed/24806526 http://dx.doi.org/10.1021/nn405839n

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