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Genome-Wide Prediction and Validation of Peptides That Bind Human Prosurvival Bcl-2 Proteins

Programmed cell death is regulated by interactions between pro-apoptotic and prosurvival members of the Bcl-2 family. Pro-apoptotic family members contain a weakly conserved BH3 motif that can adopt an alpha-helical structure and bind to a groove on prosurvival partners Bcl-x(L), Bcl-w, Bcl-2, Mcl-1...

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Detalles Bibliográficos
Autores principales:	DeBartolo, Joe, Taipale, Mikko, Keating, Amy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072508/ https://www.ncbi.nlm.nih.gov/pubmed/24967846 http://dx.doi.org/10.1371/journal.pcbi.1003693

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