Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet

Rasa3 is a GTPase activating protein of the GAP1 family which targets Ras and Rap1. Ubiquitous Rasa3 catalytic inactivation in mouse results in early embryonic lethality. Here, we show that Rasa3 catalytic inactivation in mouse hematopoietic cells results in a lethal syndrome characterized by severe...

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Detalles Bibliográficos
Autores principales: Molina-Ortiz, Patricia, Polizzi, Séléna, Ramery, Eve, Gayral, Stéphanie, Delierneux, Céline, Oury, Cécile, Iwashita, Shintaro, Schurmans, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072513/
https://www.ncbi.nlm.nih.gov/pubmed/24967784
http://dx.doi.org/10.1371/journal.pgen.1004420

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