Gain and loss of function of P2X(7) receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain

BACKGROUND: Genetic causes of exaggerated or reduced pain sensitivity in humans are well known. Recently, single nucleotide polymorphisms (SNPs) in the gene P2RX7, coding for the ATP-gated ion channel P2X(7,) have been described that cause gain-of-function (GOF) and loss-of-function (LOF), respectiv...

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Detalles Bibliográficos
Autores principales: Ursu, Daniel, Ebert, Philip, Langron, Emily, Ruble, Cara, Munsie, Leanne, Zou, Wei, Fijal, Bonnie, Qian, Yue-Wei, McNearney, Terry A, Mogg, Adrian, Grubisha, Olivera, Merchant, Kalpana, Sher, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072620/
https://www.ncbi.nlm.nih.gov/pubmed/24934217
http://dx.doi.org/10.1186/1744-8069-10-37

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