Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

The cluster of virulence sensor (CovS)/responder (CovR) two-component operon (CovRS) regulates ∼15% of the genes of the Group A Streptococcal pyogenes (GAS) genome. Bacterial clones containing inactivating mutations in the covS gene have been isolated from patients with virulent invasive diseases. W...

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Detalles Bibliográficos
Autores principales: Mayfield, Jeffrey A., Liang, Zhong, Agrahari, Garima, Lee, Shaun W., Donahue, Deborah L., Ploplis, Victoria A., Castellino, Francis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072638/
https://www.ncbi.nlm.nih.gov/pubmed/24968349
http://dx.doi.org/10.1371/journal.pone.0100698

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