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Quantifying and Exploiting the Age Dependence in the Effect of Supplementary Food for Child Undernutrition

Motivated by the lack of randomized controlled trials with an intervention-free control arm in the area of child undernutrition, we fit a trivariate model of weight-for-age z score (WAZ), height-for-age z score (HAZ) and diarrhea status to data from an observational study of supplementary feeding (1...

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Autores principales: Lakkam, Milinda, Wager, Stefan, Wise, Paul H., Wein, Lawrence M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072673/
https://www.ncbi.nlm.nih.gov/pubmed/24967745
http://dx.doi.org/10.1371/journal.pone.0099632
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author Lakkam, Milinda
Wager, Stefan
Wise, Paul H.
Wein, Lawrence M.
author_facet Lakkam, Milinda
Wager, Stefan
Wise, Paul H.
Wein, Lawrence M.
author_sort Lakkam, Milinda
collection PubMed
description Motivated by the lack of randomized controlled trials with an intervention-free control arm in the area of child undernutrition, we fit a trivariate model of weight-for-age z score (WAZ), height-for-age z score (HAZ) and diarrhea status to data from an observational study of supplementary feeding (100 kCal/day for children with WAZ [Image: see text]) in 17 Guatemalan communities. Incorporating time lags, intention to treat (i.e., to give supplementary food), seasonality and age interactions, we estimate how the effect of supplementary food on WAZ, HAZ and diarrhea status varies with a child’s age. We find that the effect of supplementary food on all 3 metrics decreases linearly with age from 6 to 20 mo and has little effect after 20 mo. We derive 2 food allocation policies that myopically (i.e., looking ahead 2 mo) minimize either the underweight or stunting severity – i.e., the sum of squared WAZ or HAZ scores for all children with WAZ or HAZ [Image: see text]. A simulation study based on the statistical model predicts that the 2 derived policies reduce the underweight severity (averaged over all ages) by 13.6–14.1% and reduce the stunting severity at age 60 mo by 7.1–8.0% relative to the policy currently in use, where all policies have a budget that feeds [Image: see text]% of children. While these findings need to be confirmed on additional data sets, it appears that in a low-dose (100 kCal/day) supplementary feeding setting in Guatemala, allocating food primarily to 6–12 mo infants can reduce the severity of underweight and stunting.
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spelling pubmed-40726732014-07-02 Quantifying and Exploiting the Age Dependence in the Effect of Supplementary Food for Child Undernutrition Lakkam, Milinda Wager, Stefan Wise, Paul H. Wein, Lawrence M. PLoS One Research Article Motivated by the lack of randomized controlled trials with an intervention-free control arm in the area of child undernutrition, we fit a trivariate model of weight-for-age z score (WAZ), height-for-age z score (HAZ) and diarrhea status to data from an observational study of supplementary feeding (100 kCal/day for children with WAZ [Image: see text]) in 17 Guatemalan communities. Incorporating time lags, intention to treat (i.e., to give supplementary food), seasonality and age interactions, we estimate how the effect of supplementary food on WAZ, HAZ and diarrhea status varies with a child’s age. We find that the effect of supplementary food on all 3 metrics decreases linearly with age from 6 to 20 mo and has little effect after 20 mo. We derive 2 food allocation policies that myopically (i.e., looking ahead 2 mo) minimize either the underweight or stunting severity – i.e., the sum of squared WAZ or HAZ scores for all children with WAZ or HAZ [Image: see text]. A simulation study based on the statistical model predicts that the 2 derived policies reduce the underweight severity (averaged over all ages) by 13.6–14.1% and reduce the stunting severity at age 60 mo by 7.1–8.0% relative to the policy currently in use, where all policies have a budget that feeds [Image: see text]% of children. While these findings need to be confirmed on additional data sets, it appears that in a low-dose (100 kCal/day) supplementary feeding setting in Guatemala, allocating food primarily to 6–12 mo infants can reduce the severity of underweight and stunting. Public Library of Science 2014-06-26 /pmc/articles/PMC4072673/ /pubmed/24967745 http://dx.doi.org/10.1371/journal.pone.0099632 Text en © 2014 Lakkam et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lakkam, Milinda
Wager, Stefan
Wise, Paul H.
Wein, Lawrence M.
Quantifying and Exploiting the Age Dependence in the Effect of Supplementary Food for Child Undernutrition
title Quantifying and Exploiting the Age Dependence in the Effect of Supplementary Food for Child Undernutrition
title_full Quantifying and Exploiting the Age Dependence in the Effect of Supplementary Food for Child Undernutrition
title_fullStr Quantifying and Exploiting the Age Dependence in the Effect of Supplementary Food for Child Undernutrition
title_full_unstemmed Quantifying and Exploiting the Age Dependence in the Effect of Supplementary Food for Child Undernutrition
title_short Quantifying and Exploiting the Age Dependence in the Effect of Supplementary Food for Child Undernutrition
title_sort quantifying and exploiting the age dependence in the effect of supplementary food for child undernutrition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072673/
https://www.ncbi.nlm.nih.gov/pubmed/24967745
http://dx.doi.org/10.1371/journal.pone.0099632
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