Cargando…

Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors

Microvascular blood flow contrast is an important hemodynamic and metabolic parameter with potential to enhance in vivo breast cancer detection and therapy monitoring. Here we report on non-invasive line-scan measurements of malignant breast tumors with a hand-held optical probe in the remission geo...

Descripción completa

Detalles Bibliográficos
Autores principales: Choe, Regine, Putt, Mary E., Carlile, Peter M., Durduran, Turgut, Giammarco, Joseph M., Busch, David R., Jung, Ki Won, Czerniecki, Brian J., Tchou, Julia, Feldman, Michael D., Mies, Carolyn, Rosen, Mark A., Schnall, Mitchell D., DeMichele, Angela, Yodh, Arjun G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072684/
https://www.ncbi.nlm.nih.gov/pubmed/24967878
http://dx.doi.org/10.1371/journal.pone.0099683
_version_ 1782323003782070272
author Choe, Regine
Putt, Mary E.
Carlile, Peter M.
Durduran, Turgut
Giammarco, Joseph M.
Busch, David R.
Jung, Ki Won
Czerniecki, Brian J.
Tchou, Julia
Feldman, Michael D.
Mies, Carolyn
Rosen, Mark A.
Schnall, Mitchell D.
DeMichele, Angela
Yodh, Arjun G.
author_facet Choe, Regine
Putt, Mary E.
Carlile, Peter M.
Durduran, Turgut
Giammarco, Joseph M.
Busch, David R.
Jung, Ki Won
Czerniecki, Brian J.
Tchou, Julia
Feldman, Michael D.
Mies, Carolyn
Rosen, Mark A.
Schnall, Mitchell D.
DeMichele, Angela
Yodh, Arjun G.
author_sort Choe, Regine
collection PubMed
description Microvascular blood flow contrast is an important hemodynamic and metabolic parameter with potential to enhance in vivo breast cancer detection and therapy monitoring. Here we report on non-invasive line-scan measurements of malignant breast tumors with a hand-held optical probe in the remission geometry. The probe employs diffuse correlation spectroscopy (DCS), a near-infrared optical method that quantifies deep tissue microvascular blood flow. Tumor-to-normal perfusion ratios are derived from thirty-two human subjects. Mean (95% confidence interval) tumor-to-normal ratio using surrounding normal tissue was 2.25 (1.92–2.63); tumor-to-normal ratio using normal tissues at the corresponding tumor location in the contralateral breast was 2.27 (1.94–2.66), and using normal tissue in the contralateral breast was 2.27 (1.90–2.70). Thus, the mean tumor-to-normal ratios were significantly different from unity irrespective of the normal tissue chosen, implying that tumors have significantly higher blood flow than normal tissues. Therefore, the study demonstrates existence of breast cancer contrast in blood flow measured by DCS. The new, optically accessible cancer contrast holds potential for cancer detection and therapy monitoring applications, and it is likely to be especially useful when combined with diffuse optical spectroscopy/tomography.
format Online
Article
Text
id pubmed-4072684
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-40726842014-07-02 Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors Choe, Regine Putt, Mary E. Carlile, Peter M. Durduran, Turgut Giammarco, Joseph M. Busch, David R. Jung, Ki Won Czerniecki, Brian J. Tchou, Julia Feldman, Michael D. Mies, Carolyn Rosen, Mark A. Schnall, Mitchell D. DeMichele, Angela Yodh, Arjun G. PLoS One Research Article Microvascular blood flow contrast is an important hemodynamic and metabolic parameter with potential to enhance in vivo breast cancer detection and therapy monitoring. Here we report on non-invasive line-scan measurements of malignant breast tumors with a hand-held optical probe in the remission geometry. The probe employs diffuse correlation spectroscopy (DCS), a near-infrared optical method that quantifies deep tissue microvascular blood flow. Tumor-to-normal perfusion ratios are derived from thirty-two human subjects. Mean (95% confidence interval) tumor-to-normal ratio using surrounding normal tissue was 2.25 (1.92–2.63); tumor-to-normal ratio using normal tissues at the corresponding tumor location in the contralateral breast was 2.27 (1.94–2.66), and using normal tissue in the contralateral breast was 2.27 (1.90–2.70). Thus, the mean tumor-to-normal ratios were significantly different from unity irrespective of the normal tissue chosen, implying that tumors have significantly higher blood flow than normal tissues. Therefore, the study demonstrates existence of breast cancer contrast in blood flow measured by DCS. The new, optically accessible cancer contrast holds potential for cancer detection and therapy monitoring applications, and it is likely to be especially useful when combined with diffuse optical spectroscopy/tomography. Public Library of Science 2014-06-26 /pmc/articles/PMC4072684/ /pubmed/24967878 http://dx.doi.org/10.1371/journal.pone.0099683 Text en © 2014 Choe et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Choe, Regine
Putt, Mary E.
Carlile, Peter M.
Durduran, Turgut
Giammarco, Joseph M.
Busch, David R.
Jung, Ki Won
Czerniecki, Brian J.
Tchou, Julia
Feldman, Michael D.
Mies, Carolyn
Rosen, Mark A.
Schnall, Mitchell D.
DeMichele, Angela
Yodh, Arjun G.
Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors
title Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors
title_full Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors
title_fullStr Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors
title_full_unstemmed Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors
title_short Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors
title_sort optically measured microvascular blood flow contrast of malignant breast tumors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072684/
https://www.ncbi.nlm.nih.gov/pubmed/24967878
http://dx.doi.org/10.1371/journal.pone.0099683
work_keys_str_mv AT choeregine opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT puttmarye opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT carlilepeterm opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT durduranturgut opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT giammarcojosephm opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT buschdavidr opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT jungkiwon opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT czernieckibrianj opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT tchoujulia opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT feldmanmichaeld opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT miescarolyn opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT rosenmarka opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT schnallmitchelld opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT demicheleangela opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors
AT yodharjung opticallymeasuredmicrovascularbloodflowcontrastofmalignantbreasttumors