A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

GPBAR1 is a G protein-coupled receptor that is activated by certain bile acids and plays an important role in the regulation of bile acid synthesis, lipid metabolism, and energy homeostasis. Recent evidence suggests that GPBAR1 may also have important effects in reducing the inflammatory response th...

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Detalles Bibliográficos
Autores principales: Lewis, Nuruddeen D., Patnaude, Lori A., Pelletier, Josephine, Souza, Donald J., Lukas, Susan M., King, F. James, Hill, Jonathan D., Stefanopoulos, Dimitria E., Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G., Broermann, Andre, Kuzmich, Daniel, Harcken, Christian, Hickey, Eugene R., Modis, Louise K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072711/
https://www.ncbi.nlm.nih.gov/pubmed/24967665
http://dx.doi.org/10.1371/journal.pone.0100883

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