Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis

OBJECTIVE: To estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms (SNPs), the factor V G1691A SNP and the prothrombin G20210A SNP. DATE SOURCES: A systematic search of the English-language literature up to November 2012 was performed using Medline and EMBASE. Search terms included “preeclampsia,” “thrombophilia,” “factor V Leiden,” “prothrombin gene 20210,” and their combinations. RESULT(S): Thirty-seven studies with 5048 preeclampsia patients and 6796 controls were included in the meta-analysis. We found that the prothrombin G20210A polymorphism was associated with an increased risk of all preeclampsia (pooled odds ratio (OR) = 1.81, 95% confidence interval (CI) 1.25–2.63) and severe preeclampsia (pooled OR = 3.02, 95%CI 2.06–4.45). Meanwhile, the pooled OR for the association between factor V Leiden and all preeclampsia was 1.60 (95%CI 1.28–2.00) and 2.45 (95%CI 1.63–3.69) for the cases of severe preeclampsia. CONCLUSION(S): This meta-analysis supports that the factor V G1691A SNP and the prothrombin G20210A SNP are associated with an increased risk for both preeclampsia overall and severe preeclampsia.