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Human IGF1 Regulates Midgut Oxidative Stress and Epithelial Homeostasis to Balance Lifespan and Plasmodium falciparum resistance in Anopheles stephensi
Insulin and insulin-like growth factor signaling (IIS) regulates cell death, repair, autophagy, and renewal in response to stress, damage, and pathogen challenge. Therefore, IIS is fundamental to lifespan and disease resistance. Previously, we showed that insulin-like growth factor 1 (IGF1) within a...
Autores principales: | Drexler, Anna L., Pietri, Jose E., Pakpour, Nazzy, Hauck, Eric, Wang, Bo, Glennon, Elizabeth K. K., Georgis, Martha, Riehle, Michael A., Luckhart, Shirley |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072789/ https://www.ncbi.nlm.nih.gov/pubmed/24968248 http://dx.doi.org/10.1371/journal.ppat.1004231 |
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