Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents

The fidelity of NMDA receptors (NMDARs) to integrate pre- and post-synaptic activity requires a match between agonist binding and ion channel opening. To address how agonist binding is transduced into pore opening in NMDARs, we manipulated the coupling between the ligand binding domain (LBD) and the...

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Detalles Bibliográficos
Autores principales: Kazi, Rashek, Dai, Jian, Sweeney, Cameron, Zhou, Huan-Xiang, Wollmuth, Lonnie P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072853/
https://www.ncbi.nlm.nih.gov/pubmed/24859202
http://dx.doi.org/10.1038/nn.3724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072853/
https://www.ncbi.nlm.nih.gov/pubmed/24859202
http://dx.doi.org/10.1038/nn.3724

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