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Hypermethylation in the ZBTB20 gene is associated with major depressive disorder
BACKGROUND: Although genetic variation is believed to contribute to an individual’s susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology of the disease. Epigenetics is increasingly believed to play a ma...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072999/ https://www.ncbi.nlm.nih.gov/pubmed/24694013 http://dx.doi.org/10.1186/gb-2014-15-4-r56 |
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author | Davies, Matthew N Krause, Lutz Bell, Jordana T Gao, Fei Ward, Kirsten J Wu, Honglong Lu, Hanlin Liu, Yuan Tsai, Pei-Chein Collier, David A Murphy, Therese Dempster, Emma Mill, Jonathan Battle, Alexis Mostafavi, Sara Zhu, Xiaowei Henders, Anjali Byrne, Enda Wray, Naomi R Martin, Nicholas G Spector, Tim D Wang, Jun |
author_facet | Davies, Matthew N Krause, Lutz Bell, Jordana T Gao, Fei Ward, Kirsten J Wu, Honglong Lu, Hanlin Liu, Yuan Tsai, Pei-Chein Collier, David A Murphy, Therese Dempster, Emma Mill, Jonathan Battle, Alexis Mostafavi, Sara Zhu, Xiaowei Henders, Anjali Byrne, Enda Wray, Naomi R Martin, Nicholas G Spector, Tim D Wang, Jun |
author_sort | Davies, Matthew N |
collection | PubMed |
description | BACKGROUND: Although genetic variation is believed to contribute to an individual’s susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology of the disease. Epigenetics is increasingly believed to play a major role in the development of common clinical phenotypes, including major depressive disorder. RESULTS: Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20, and is replicated in an independent cohort of 356 unrelated case-control individuals. The twins with major depressive disorder also show increased global variation in methylation in comparison with their unaffected co-twins. ZBTB20 plays an essential role in the specification of the Cornu Ammonis-1 field identity in the developing hippocampus, a region previously implicated in the development of major depressive disorder. CONCLUSIONS: Our results suggest that aberrant methylation profiles affecting the hippocampus are associated with major depressive disorder and show the potential of the epigenetic twin model in neuro-psychiatric disease. |
format | Online Article Text |
id | pubmed-4072999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40729992014-06-28 Hypermethylation in the ZBTB20 gene is associated with major depressive disorder Davies, Matthew N Krause, Lutz Bell, Jordana T Gao, Fei Ward, Kirsten J Wu, Honglong Lu, Hanlin Liu, Yuan Tsai, Pei-Chein Collier, David A Murphy, Therese Dempster, Emma Mill, Jonathan Battle, Alexis Mostafavi, Sara Zhu, Xiaowei Henders, Anjali Byrne, Enda Wray, Naomi R Martin, Nicholas G Spector, Tim D Wang, Jun Genome Biol Research BACKGROUND: Although genetic variation is believed to contribute to an individual’s susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology of the disease. Epigenetics is increasingly believed to play a major role in the development of common clinical phenotypes, including major depressive disorder. RESULTS: Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20, and is replicated in an independent cohort of 356 unrelated case-control individuals. The twins with major depressive disorder also show increased global variation in methylation in comparison with their unaffected co-twins. ZBTB20 plays an essential role in the specification of the Cornu Ammonis-1 field identity in the developing hippocampus, a region previously implicated in the development of major depressive disorder. CONCLUSIONS: Our results suggest that aberrant methylation profiles affecting the hippocampus are associated with major depressive disorder and show the potential of the epigenetic twin model in neuro-psychiatric disease. BioMed Central 2014 2014-04-02 /pmc/articles/PMC4072999/ /pubmed/24694013 http://dx.doi.org/10.1186/gb-2014-15-4-r56 Text en Copyright © 2014 Davies et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Davies, Matthew N Krause, Lutz Bell, Jordana T Gao, Fei Ward, Kirsten J Wu, Honglong Lu, Hanlin Liu, Yuan Tsai, Pei-Chein Collier, David A Murphy, Therese Dempster, Emma Mill, Jonathan Battle, Alexis Mostafavi, Sara Zhu, Xiaowei Henders, Anjali Byrne, Enda Wray, Naomi R Martin, Nicholas G Spector, Tim D Wang, Jun Hypermethylation in the ZBTB20 gene is associated with major depressive disorder |
title | Hypermethylation in the ZBTB20 gene is associated with major depressive disorder |
title_full | Hypermethylation in the ZBTB20 gene is associated with major depressive disorder |
title_fullStr | Hypermethylation in the ZBTB20 gene is associated with major depressive disorder |
title_full_unstemmed | Hypermethylation in the ZBTB20 gene is associated with major depressive disorder |
title_short | Hypermethylation in the ZBTB20 gene is associated with major depressive disorder |
title_sort | hypermethylation in the zbtb20 gene is associated with major depressive disorder |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072999/ https://www.ncbi.nlm.nih.gov/pubmed/24694013 http://dx.doi.org/10.1186/gb-2014-15-4-r56 |
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