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Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome

Irritable bowel syndrome (IBS) is a very frequent functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort and alteration of bowel habits. The IBS physiopathology is extremely complex. Visceral hypersensitivity plays an important role in the pathogenesis of abdomi...

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Autores principales: de Carvalho Rocha, Heraldo Arcela, Dantas, Bruna Priscilla Vasconcelos, Rolim, Thaísa Leite, Costa, Bagnólia Araújo, de Medeiros, Arnaldo Correia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Gastroenterology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073014/
https://www.ncbi.nlm.nih.gov/pubmed/24976114
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author de Carvalho Rocha, Heraldo Arcela
Dantas, Bruna Priscilla Vasconcelos
Rolim, Thaísa Leite
Costa, Bagnólia Araújo
de Medeiros, Arnaldo Correia
author_facet de Carvalho Rocha, Heraldo Arcela
Dantas, Bruna Priscilla Vasconcelos
Rolim, Thaísa Leite
Costa, Bagnólia Araújo
de Medeiros, Arnaldo Correia
author_sort de Carvalho Rocha, Heraldo Arcela
collection PubMed
description Irritable bowel syndrome (IBS) is a very frequent functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort and alteration of bowel habits. The IBS physiopathology is extremely complex. Visceral hypersensitivity plays an important role in the pathogenesis of abdominal pain in both in vitro and in vivo models of this functional disorder. In order to obtain a general view of the participation of the main ion channels and receptors regarding the visceral hypersensitivity in the IBS and to describe their chemical structure, a literature review was carried out. A bibliographical research in the following electronic databases: Pubmed and Virtual Library in Health (BVS) was fulfilled by using the search terms “ion channels” “or” “receptors” “and” “visceral hypersensitivity” “or” “visceral nociception” “and” “irritable bowel syndrome”. Original and review articles were considered for data acquisition. The activation of the ATP ion-gated channels, voltage-gated sodium (Na(v)) and calcium (Ca(v)) channels, as well as the activation of protease-activated receptors (PAR2), transient receptor potential vanilloide-1, serotonin, cannabinoids and cholecystokinin are involved in the genesis of visceral hypersensitivity in IBS. The involvement of ion channels and receptors concerning visceral hypersensitivity is noteworthy in IBS models.
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spelling pubmed-40730142014-06-27 Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome de Carvalho Rocha, Heraldo Arcela Dantas, Bruna Priscilla Vasconcelos Rolim, Thaísa Leite Costa, Bagnólia Araújo de Medeiros, Arnaldo Correia Ann Gastroenterol Review Irritable bowel syndrome (IBS) is a very frequent functional gastrointestinal disorder characterized by recurrent abdominal pain or discomfort and alteration of bowel habits. The IBS physiopathology is extremely complex. Visceral hypersensitivity plays an important role in the pathogenesis of abdominal pain in both in vitro and in vivo models of this functional disorder. In order to obtain a general view of the participation of the main ion channels and receptors regarding the visceral hypersensitivity in the IBS and to describe their chemical structure, a literature review was carried out. A bibliographical research in the following electronic databases: Pubmed and Virtual Library in Health (BVS) was fulfilled by using the search terms “ion channels” “or” “receptors” “and” “visceral hypersensitivity” “or” “visceral nociception” “and” “irritable bowel syndrome”. Original and review articles were considered for data acquisition. The activation of the ATP ion-gated channels, voltage-gated sodium (Na(v)) and calcium (Ca(v)) channels, as well as the activation of protease-activated receptors (PAR2), transient receptor potential vanilloide-1, serotonin, cannabinoids and cholecystokinin are involved in the genesis of visceral hypersensitivity in IBS. The involvement of ion channels and receptors concerning visceral hypersensitivity is noteworthy in IBS models. Hellenic Society of Gastroenterology 2014 /pmc/articles/PMC4073014/ /pubmed/24976114 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
de Carvalho Rocha, Heraldo Arcela
Dantas, Bruna Priscilla Vasconcelos
Rolim, Thaísa Leite
Costa, Bagnólia Araújo
de Medeiros, Arnaldo Correia
Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome
title Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome
title_full Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome
title_fullStr Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome
title_full_unstemmed Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome
title_short Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome
title_sort main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073014/
https://www.ncbi.nlm.nih.gov/pubmed/24976114
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