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Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis
BACKGROUND: RNA interference (RNAi) is an effective and important tool used to study gene function. For large-scale screens, RNAi is used to systematically down-regulate genes of interest and analyze their roles in a biological process. However, RNAi is associated with off-target effects (OTEs), inc...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073188/ https://www.ncbi.nlm.nih.gov/pubmed/24934636 http://dx.doi.org/10.1186/1471-2105-15-192 |