Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

Neuregulin 1 (NRG1) and the γ-secretase subunit APH1B have been previously implicated as genetic risk factors for schizophrenia and schizophrenia relevant deficits have been observed in rodent models with loss of function mutations in either gene. Here we show that the Aph1b-γ-secretase is selective...

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Detalles Bibliográficos
Autores principales: Fazzari, Pietro, Snellinx, An, Sabanov, Victor, Ahmed, Tariq, Serneels, Lutgarde, Gartner, Annette, Shariati, S Ali M, Balschun, Detlef, De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073283/
https://www.ncbi.nlm.nih.gov/pubmed/24891237
http://dx.doi.org/10.7554/eLife.02196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073283/
https://www.ncbi.nlm.nih.gov/pubmed/24891237
http://dx.doi.org/10.7554/eLife.02196

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