Prostaglandin E(2) acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro

Intermittent PTH is the major anabolic therapy for osteoporosis while continuous PTH causes bone loss. PTH acts on the osteoblast (OB) lineage to regulate bone resorption and formation. PTH also induces cyclooxygenase-2 (COX-2), producing prostaglandin E(2) (PGE(2)) that can act on both OBs and oste...

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Detalles Bibliográficos
Autores principales: Choudhary, Shilpa, Blackwell, Katherine, Voznesensky, Olga, Roy, Abhijit Deb, Pilbeam, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073290/
https://www.ncbi.nlm.nih.gov/pubmed/23639875
http://dx.doi.org/10.1016/j.bone.2013.04.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073290/
https://www.ncbi.nlm.nih.gov/pubmed/23639875
http://dx.doi.org/10.1016/j.bone.2013.04.017

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