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Prostaglandin E(2) acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro
Intermittent PTH is the major anabolic therapy for osteoporosis while continuous PTH causes bone loss. PTH acts on the osteoblast (OB) lineage to regulate bone resorption and formation. PTH also induces cyclooxygenase-2 (COX-2), producing prostaglandin E(2) (PGE(2)) that can act on both OBs and oste...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073290/ https://www.ncbi.nlm.nih.gov/pubmed/23639875 http://dx.doi.org/10.1016/j.bone.2013.04.017 |