N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs

This study aimed to investigate the therapeutic effects of N-acetyl-D-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improve...

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Autores principales: NAGASAWA, Miho, SHIMOZAWA, Aki, MOGI, Kazutaka, KIKUSUI, Takefumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073348/
https://www.ncbi.nlm.nih.gov/pubmed/24430654
http://dx.doi.org/10.1292/jvms.13-0351
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author NAGASAWA, Miho
SHIMOZAWA, Aki
MOGI, Kazutaka
KIKUSUI, Takefumi
author_facet NAGASAWA, Miho
SHIMOZAWA, Aki
MOGI, Kazutaka
KIKUSUI, Takefumi
author_sort NAGASAWA, Miho
collection PubMed
description This study aimed to investigate the therapeutic effects of N-acetyl-D-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error trials in the place-learning test, especially in the first month of administration. Three ManNAc-treated dogs also showed improvement in the active-resting cycle. In conclusion, ManNAc treatment appears to alleviate age-related cognitive dysfunction.
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spelling pubmed-40733482014-06-27 N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs NAGASAWA, Miho SHIMOZAWA, Aki MOGI, Kazutaka KIKUSUI, Takefumi J Vet Med Sci Pharmacology This study aimed to investigate the therapeutic effects of N-acetyl-D-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error trials in the place-learning test, especially in the first month of administration. Three ManNAc-treated dogs also showed improvement in the active-resting cycle. In conclusion, ManNAc treatment appears to alleviate age-related cognitive dysfunction. The Japanese Society of Veterinary Science 2014-01-16 2014-05 /pmc/articles/PMC4073348/ /pubmed/24430654 http://dx.doi.org/10.1292/jvms.13-0351 Text en ©2014 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Pharmacology
NAGASAWA, Miho
SHIMOZAWA, Aki
MOGI, Kazutaka
KIKUSUI, Takefumi
N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs
title N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs
title_full N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs
title_fullStr N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs
title_full_unstemmed N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs
title_short N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs
title_sort n-acetyl-d-mannosamine treatment alleviates age-related decline in place-learning ability in dogs
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073348/
https://www.ncbi.nlm.nih.gov/pubmed/24430654
http://dx.doi.org/10.1292/jvms.13-0351
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