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Properties of novel composite meshes in chest wall reconstruction: A comparative animal study

PURPOSE: Novel composite meshes routinely used in laparoscopic hernia repair reportedly lead to fewer and less dense visceral adhesions and may provide a viable alternative in thoracic surgery as well. METHODS: A total of 15 adult domestic pigs underwent full thickness chest wall resection and recon...

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Autores principales: Zardo, Patrick, Zhang, Ruoyu, Freermann, Stefan, Fischer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073573/
https://www.ncbi.nlm.nih.gov/pubmed/24987475
http://dx.doi.org/10.4103/1817-1737.134071
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author Zardo, Patrick
Zhang, Ruoyu
Freermann, Stefan
Fischer, Stefan
author_facet Zardo, Patrick
Zhang, Ruoyu
Freermann, Stefan
Fischer, Stefan
author_sort Zardo, Patrick
collection PubMed
description PURPOSE: Novel composite meshes routinely used in laparoscopic hernia repair reportedly lead to fewer and less dense visceral adhesions and may provide a viable alternative in thoracic surgery as well. METHODS: A total of 15 adult domestic pigs underwent full thickness chest wall resection and reconstruction with Parietene (polypropylene composite; PTE, n = 5), Parietex (polyester composite; PTX, n = 5) or Bard (purely polypropylene, n = 5) mesh. After an observation period of 90 days all animals were sacrificed, intrathoracic adhesions classified via thoracoscopy (VATS), meshes explanted and peak peal strength required for lung/mesh separation recorded. RESULTS: Adhesions assessed through VATS-exploration were strongest in the PTX-Group while PTE and BM showed comparable results. Tensiometric analyses of peak peal strength confirmed lower values in BM than for PTE and PTX. Both composite materials showed good overall bioincorporation with post-surgical perigraft-fibrosis being strongest in BM. CONCLUSION: We consider composite grafts a suitable alternative for chest wall reconstruction. They are characterized by good overall biointegration and limited perigraft-fibrosis, thus potentially facilitating redo-procedures, even though a hydrophilic coating per se does not appear to prevent intrathoracic adhesion formation.
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spelling pubmed-40735732014-07-02 Properties of novel composite meshes in chest wall reconstruction: A comparative animal study Zardo, Patrick Zhang, Ruoyu Freermann, Stefan Fischer, Stefan Ann Thorac Med Original Article PURPOSE: Novel composite meshes routinely used in laparoscopic hernia repair reportedly lead to fewer and less dense visceral adhesions and may provide a viable alternative in thoracic surgery as well. METHODS: A total of 15 adult domestic pigs underwent full thickness chest wall resection and reconstruction with Parietene (polypropylene composite; PTE, n = 5), Parietex (polyester composite; PTX, n = 5) or Bard (purely polypropylene, n = 5) mesh. After an observation period of 90 days all animals were sacrificed, intrathoracic adhesions classified via thoracoscopy (VATS), meshes explanted and peak peal strength required for lung/mesh separation recorded. RESULTS: Adhesions assessed through VATS-exploration were strongest in the PTX-Group while PTE and BM showed comparable results. Tensiometric analyses of peak peal strength confirmed lower values in BM than for PTE and PTX. Both composite materials showed good overall bioincorporation with post-surgical perigraft-fibrosis being strongest in BM. CONCLUSION: We consider composite grafts a suitable alternative for chest wall reconstruction. They are characterized by good overall biointegration and limited perigraft-fibrosis, thus potentially facilitating redo-procedures, even though a hydrophilic coating per se does not appear to prevent intrathoracic adhesion formation. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4073573/ /pubmed/24987475 http://dx.doi.org/10.4103/1817-1737.134071 Text en Copyright: © Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zardo, Patrick
Zhang, Ruoyu
Freermann, Stefan
Fischer, Stefan
Properties of novel composite meshes in chest wall reconstruction: A comparative animal study
title Properties of novel composite meshes in chest wall reconstruction: A comparative animal study
title_full Properties of novel composite meshes in chest wall reconstruction: A comparative animal study
title_fullStr Properties of novel composite meshes in chest wall reconstruction: A comparative animal study
title_full_unstemmed Properties of novel composite meshes in chest wall reconstruction: A comparative animal study
title_short Properties of novel composite meshes in chest wall reconstruction: A comparative animal study
title_sort properties of novel composite meshes in chest wall reconstruction: a comparative animal study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073573/
https://www.ncbi.nlm.nih.gov/pubmed/24987475
http://dx.doi.org/10.4103/1817-1737.134071
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