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Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung

Propagation-based X-ray phase-contrast computed tomography (PBI) has already proven its potential in a great variety of soft-tissue-related applications including lung imaging. However, the strong edge enhancement, caused by the phase effects, often hampers image segmentation and therefore the quant...

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Autores principales: Mohammadi, Sara, Larsson, Emanuel, Alves, Frauke, Dal Monego, Simeone, Biffi, Stefania, Garrovo, Chiara, Lorenzon, Andrea, Tromba, Giuliana, Dullin, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073959/
https://www.ncbi.nlm.nih.gov/pubmed/24971975
http://dx.doi.org/10.1107/S1600577514009333
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author Mohammadi, Sara
Larsson, Emanuel
Alves, Frauke
Dal Monego, Simeone
Biffi, Stefania
Garrovo, Chiara
Lorenzon, Andrea
Tromba, Giuliana
Dullin, Christian
author_facet Mohammadi, Sara
Larsson, Emanuel
Alves, Frauke
Dal Monego, Simeone
Biffi, Stefania
Garrovo, Chiara
Lorenzon, Andrea
Tromba, Giuliana
Dullin, Christian
author_sort Mohammadi, Sara
collection PubMed
description Propagation-based X-ray phase-contrast computed tomography (PBI) has already proven its potential in a great variety of soft-tissue-related applications including lung imaging. However, the strong edge enhancement, caused by the phase effects, often hampers image segmentation and therefore the quantitative analysis of data sets. Here, the benefits of applying single-distance phase retrieval prior to the three-dimensional reconstruction (PhR) are discussed and quantified compared with three-dimensional reconstructions of conventional PBI data sets in terms of contrast-to-noise ratio (CNR) and preservation of image features. The PhR data sets show more than a tenfold higher CNR and only minor blurring of the edges when compared with PBI in a predominately absorption-based set-up. Accordingly, phase retrieval increases the sensitivity and provides more functionality in computed tomography imaging.
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spelling pubmed-40739592014-07-16 Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung Mohammadi, Sara Larsson, Emanuel Alves, Frauke Dal Monego, Simeone Biffi, Stefania Garrovo, Chiara Lorenzon, Andrea Tromba, Giuliana Dullin, Christian J Synchrotron Radiat Research Papers Propagation-based X-ray phase-contrast computed tomography (PBI) has already proven its potential in a great variety of soft-tissue-related applications including lung imaging. However, the strong edge enhancement, caused by the phase effects, often hampers image segmentation and therefore the quantitative analysis of data sets. Here, the benefits of applying single-distance phase retrieval prior to the three-dimensional reconstruction (PhR) are discussed and quantified compared with three-dimensional reconstructions of conventional PBI data sets in terms of contrast-to-noise ratio (CNR) and preservation of image features. The PhR data sets show more than a tenfold higher CNR and only minor blurring of the edges when compared with PBI in a predominately absorption-based set-up. Accordingly, phase retrieval increases the sensitivity and provides more functionality in computed tomography imaging. International Union of Crystallography 2014-05-16 /pmc/articles/PMC4073959/ /pubmed/24971975 http://dx.doi.org/10.1107/S1600577514009333 Text en © Sara Mohammadi et al. 2014 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Papers
Mohammadi, Sara
Larsson, Emanuel
Alves, Frauke
Dal Monego, Simeone
Biffi, Stefania
Garrovo, Chiara
Lorenzon, Andrea
Tromba, Giuliana
Dullin, Christian
Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung
title Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung
title_full Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung
title_fullStr Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung
title_full_unstemmed Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung
title_short Quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung
title_sort quantitative evaluation of a single-distance phase-retrieval method applied on in-line phase-contrast images of a mouse lung
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073959/
https://www.ncbi.nlm.nih.gov/pubmed/24971975
http://dx.doi.org/10.1107/S1600577514009333
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