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Aberrant Topoisomerase-1-DNA Lesions are Pathogenic in Neurodegenerative Genome Instability Syndromes

DNA damage is considered a prime factor in multiple spinocerebellar neurodegenerative diseases; however, the DNA lesions underpinning disease etiology are unknown. Here we identify the endogenous accumulation of pathogenic topoisomerase-1-DNA cleavage complexes (Top1cc) in murine models of ataxia te...

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Detalles Bibliográficos
Autores principales:	Katyal, Sachin, Lee, Youngsoo, Nitiss, Karin C., Downing, Susanna M., Li, Yang, Shimada, Mikio, Zhao, Jingfeng, Russell, Helen R., Petrini, John H. J., Nitiss, John L., McKinnon, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074009/ https://www.ncbi.nlm.nih.gov/pubmed/24793032 http://dx.doi.org/10.1038/nn.3715

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