Comparing Chemistry to Outcome: The Development of a Chemical Distance Metric, Coupled with Clustering and Hierarchal Visualization Applied to Macromolecular Crystallography

Many bioscience fields employ high-throughput methods to screen multiple biochemical conditions. The analysis of these becomes tedious without a degree of automation. Crystallization, a rate limiting step in biological X-ray crystallography, is one of these fields. Screening of multiple potential cr...

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Detalles Bibliográficos
Autores principales: Bruno, Andrew E., Ruby, Amanda M., Luft, Joseph R., Grant, Thomas D., Seetharaman, Jayaraman, Montelione, Gaetano T., Hunt, John F., Snell, Edward H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074061/
https://www.ncbi.nlm.nih.gov/pubmed/24971458
http://dx.doi.org/10.1371/journal.pone.0100782

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