Host Competence and Helicase Activity Differences Exhibited by West Nile Viral Variants Expressing NS3-249 Amino Acid Polymorphisms

A single helicase amino acid substitution, NS3-T249P, has been shown to increase viremia magnitude/mortality in American crows (AMCRs) following West Nile virus (WNV) infection. Lineage/intra-lineage geographic variants exhibit consistent amino acid polymorphisms at this locus; however, the majority...

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Detalles Bibliográficos
Autores principales: Langevin, Stanley A., Bowen, Richard A., Reisen, William K., Andrade, Christy C., Ramey, Wanichaya N., Maharaj, Payal D., Anishchenko, Michael, Kenney, Joan L., Duggal, Nisha K., Romo, Hannah, Bera, Aloke Kumar, Sanders, Todd A., Bosco-Lauth, Angela, Smith, Janet L., Kuhn, Richard, Brault, Aaron C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074097/
https://www.ncbi.nlm.nih.gov/pubmed/24971589
http://dx.doi.org/10.1371/journal.pone.0100802

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