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FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation

BACKGROUND: Heat shock protein 90 (Hsp90) is a promising therapeutic target and inhibition of Hsp90 will presumably result in suppression of multiple signaling pathways. FW-04-806, a bis-oxazolyl macrolide compound extracted from China-native Streptomyces FIM-04-806, was reported to be identical in...

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Detalles Bibliográficos
Autores principales:	Huang, Wei, Ye, Min, Zhang, Lian-ru, Wu, Qun-dan, Zhang, Min, Xu, Jian-hua, Zheng, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074137/ https://www.ncbi.nlm.nih.gov/pubmed/24927996 http://dx.doi.org/10.1186/1476-4598-13-150

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