SUMO3 Modification Accelerates the Aggregation of ALS-Linked SOD1 Mutants

Mutations in superoxide dismutase 1 (SOD1) are a major cause of familial amyotrophic lateral sclerosis (ALS), whereby the mutant proteins misfold and aggregate to form intracellular inclusions. We report that both small ubiquitin-like modifier (SUMO) 1 and SUMO2/3 modify ALS-linked SOD1 mutant prote...

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Detalles Bibliográficos
Autores principales: Niikura, Takako, Kita, Yoshiko, Abe, Yoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074151/
https://www.ncbi.nlm.nih.gov/pubmed/24971881
http://dx.doi.org/10.1371/journal.pone.0101080

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