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Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis

To date, the role of dopamine D1 receptor (DRD1) polymorphism in schizophrenia remains controversial. We carried out a meta-analysis to determine whether DRD1 polymorphism influences the risk of schizophrenia. We examined whether rs4532 and rs5326 genetic variants are related to the etiology of schi...

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Autores principales: Pan, Yuqing, Yao, Jun, Wang, Baojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074178/
https://www.ncbi.nlm.nih.gov/pubmed/25018632
http://dx.doi.org/10.2147/NDT.S63776
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author Pan, Yuqing
Yao, Jun
Wang, Baojie
author_facet Pan, Yuqing
Yao, Jun
Wang, Baojie
author_sort Pan, Yuqing
collection PubMed
description To date, the role of dopamine D1 receptor (DRD1) polymorphism in schizophrenia remains controversial. We carried out a meta-analysis to determine whether DRD1 polymorphism influences the risk of schizophrenia. We examined whether rs4532 and rs5326 genetic variants are related to the etiology of schizophrenia, using a meta-analysis. Relevant case-control studies were retrieved by database searching and selected according to established inclusion criteria. A total of ten studies were identified and included in our meta-analysis, nine for rs4532, with 1,941 cases and 2,480 controls, and four for rs5326, with 1,285 cases and 1,195 controls. No significant association was found between the rs4532 locus and schizophrenia. For the rs5326 locus, the guanine-adenine (GA) genotype was associated with schizophrenia as a risk factor (for GA vs guanine-guanine [GG], odds ratio [OR] =1.36, 95% confidence interval [CI]: 1.15–1.61, P<0.001). The GA genotype of rs5326 increased the risk of schizophrenia, but there was no association between rs4532 and schizophrenia. These data may provide references for case-control studies in schizophrenia in future.
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spelling pubmed-40741782014-07-11 Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis Pan, Yuqing Yao, Jun Wang, Baojie Neuropsychiatr Dis Treat Original Research To date, the role of dopamine D1 receptor (DRD1) polymorphism in schizophrenia remains controversial. We carried out a meta-analysis to determine whether DRD1 polymorphism influences the risk of schizophrenia. We examined whether rs4532 and rs5326 genetic variants are related to the etiology of schizophrenia, using a meta-analysis. Relevant case-control studies were retrieved by database searching and selected according to established inclusion criteria. A total of ten studies were identified and included in our meta-analysis, nine for rs4532, with 1,941 cases and 2,480 controls, and four for rs5326, with 1,285 cases and 1,195 controls. No significant association was found between the rs4532 locus and schizophrenia. For the rs5326 locus, the guanine-adenine (GA) genotype was associated with schizophrenia as a risk factor (for GA vs guanine-guanine [GG], odds ratio [OR] =1.36, 95% confidence interval [CI]: 1.15–1.61, P<0.001). The GA genotype of rs5326 increased the risk of schizophrenia, but there was no association between rs4532 and schizophrenia. These data may provide references for case-control studies in schizophrenia in future. Dove Medical Press 2014-06-20 /pmc/articles/PMC4074178/ /pubmed/25018632 http://dx.doi.org/10.2147/NDT.S63776 Text en © 2014 Pan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Pan, Yuqing
Yao, Jun
Wang, Baojie
Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_full Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_fullStr Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_full_unstemmed Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_short Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis
title_sort association of dopamine d1 receptor gene polymorphism with schizophrenia: a meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074178/
https://www.ncbi.nlm.nih.gov/pubmed/25018632
http://dx.doi.org/10.2147/NDT.S63776
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