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Granzyme B Releases Vascular Endothelial Growth Factor from Extracellular Matrix and Induces Vascular Permeability

The formation of unstable, leaky neovessels underlies the pathogenesis of many chronic inflammatory diseases. Granzyme B (GZMB) is an immune-derived serine protease that accumulates in the extracellular matrix (ECM) during chronic inflammation and is capable of cleaving fibronectin (FN). Vascular en...

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Detalles Bibliográficos
Autores principales:	Hendel, Alon, Hsu, Ivy, Granville, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074428/ https://www.ncbi.nlm.nih.gov/pubmed/24791744 http://dx.doi.org/10.1038/labinvest.2014.62

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