Hepatoprotective role of Sestrin2 against chronic ER stress

Upon prolonged endoplasmic reticulum (ER) stress, cells attenuate protein translation to prevent accumulation of unfolded proteins. Here we show that Sestrin2 is critical for this process. Sestrin2 expression is induced by an ER stress-activated transcription factor CCAAT-enhancer-binding protein be...

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Detalles Bibliográficos
Autores principales: Park, Hwan-Woo, Park, Haeli, Ro, Seung-Hyun, Jang, Insook, Semple, Ian A., Kim, David N., Kim, Myungjin, Nam, Myeongjin, Zhang, Deqiang, Yin, Lei, Lee, Jun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074707/
https://www.ncbi.nlm.nih.gov/pubmed/24947615
http://dx.doi.org/10.1038/ncomms5233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074707/
https://www.ncbi.nlm.nih.gov/pubmed/24947615
http://dx.doi.org/10.1038/ncomms5233

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