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MicroRNAs in the Regulation of MMPs and Metastasis
MicroRNAs are integral molecules in the regulation of numerous physiological cellular processes including cellular differentiation, proliferation, metabolism and apoptosis. Their function transcends normal physiology and extends into several pathological entities including cancer. The matrix metallo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074795/ https://www.ncbi.nlm.nih.gov/pubmed/24670365 http://dx.doi.org/10.3390/cancers6020625 |
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author | Abba, Mohammed Patil, Nitin Allgayer, Heike |
author_facet | Abba, Mohammed Patil, Nitin Allgayer, Heike |
author_sort | Abba, Mohammed |
collection | PubMed |
description | MicroRNAs are integral molecules in the regulation of numerous physiological cellular processes including cellular differentiation, proliferation, metabolism and apoptosis. Their function transcends normal physiology and extends into several pathological entities including cancer. The matrix metalloproteinases play pivotal roles, not only in tissue remodeling, but also in several physiological and pathological processes, including those supporting cancer progression. Additionally, the contribution of active MMPs in metastatic spread and the establishment of secondary metastasis, via the targeting of several substrates, are also well established. This review focuses on the important miRNAs that have been found to impact cancer progression and metastasis through direct and indirect interactions with the matrix metalloproteinases. |
format | Online Article Text |
id | pubmed-4074795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40747952014-06-30 MicroRNAs in the Regulation of MMPs and Metastasis Abba, Mohammed Patil, Nitin Allgayer, Heike Cancers (Basel) Review MicroRNAs are integral molecules in the regulation of numerous physiological cellular processes including cellular differentiation, proliferation, metabolism and apoptosis. Their function transcends normal physiology and extends into several pathological entities including cancer. The matrix metalloproteinases play pivotal roles, not only in tissue remodeling, but also in several physiological and pathological processes, including those supporting cancer progression. Additionally, the contribution of active MMPs in metastatic spread and the establishment of secondary metastasis, via the targeting of several substrates, are also well established. This review focuses on the important miRNAs that have been found to impact cancer progression and metastasis through direct and indirect interactions with the matrix metalloproteinases. MDPI 2014-03-25 /pmc/articles/PMC4074795/ /pubmed/24670365 http://dx.doi.org/10.3390/cancers6020625 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Abba, Mohammed Patil, Nitin Allgayer, Heike MicroRNAs in the Regulation of MMPs and Metastasis |
title | MicroRNAs in the Regulation of MMPs and Metastasis |
title_full | MicroRNAs in the Regulation of MMPs and Metastasis |
title_fullStr | MicroRNAs in the Regulation of MMPs and Metastasis |
title_full_unstemmed | MicroRNAs in the Regulation of MMPs and Metastasis |
title_short | MicroRNAs in the Regulation of MMPs and Metastasis |
title_sort | micrornas in the regulation of mmps and metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074795/ https://www.ncbi.nlm.nih.gov/pubmed/24670365 http://dx.doi.org/10.3390/cancers6020625 |
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