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Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis

The fragile FHIT gene, encompassing the chromosomal fragile site FRA3B, is an early target of DNA damage in precancerous cells. While vulnerable to DNA damage itself, FHIT protein expression is essential to protect from DNA damage-induced cancer initiation and progression by modulating genome stabil...

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Detalles Bibliográficos
Autores principales:	Karras, Jenna R., Paisie, Carolyn A., Huebner, Kay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074825/ https://www.ncbi.nlm.nih.gov/pubmed/24901304 http://dx.doi.org/10.3390/cancers6021208

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