Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer

BACKGROUND: We previously reported the clinical efficacy of adoptive immunotherapy (AIT) with dendritic cells (DCs) pulsed with mucin 1 (MUC1) peptide and cytotoxic T lymphocytes (CTLs). We also reported that gemcitabine (GEM) enhances anti-tumor immunity by suppressing regulatory T cells. Therefore...

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Detalles Bibliográficos
Autores principales: Shindo, Yoshitaro, Hazama, Shoichi, Maeda, Yoshinari, Matsui, Hiroto, Iida, Michihisa, Suzuki, Nobuaki, Yoshimura, Kiyoshi, Ueno, Tomio, Yoshino, Shigefumi, Sakai, Kohei, Suehiro, Yutaka, Yamasaki, Takahiro, Hinoda, Yuji, Oka, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074851/
https://www.ncbi.nlm.nih.gov/pubmed/24947606
http://dx.doi.org/10.1186/1479-5876-12-175

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