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Engineered RNase P Ribozymes Effectively Inhibit Human Cytomegalovirus Gene Expression and Replication

RNase P ribozyme can be engineered to be a sequence-specific gene-targeting agent with promising application in both basic research and clinical settings. By using an in vitro selection system, we have previously generated RNase P ribozyme variants that have better catalytic activity in cleaving an...

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Detalles Bibliográficos
Autores principales:	Yang, Zhu, Vu, Gia-Phong, Qian, Hua, Chen, Yuan-Chuan, Wang, Yu, Reeves, Michael, Zen, Ke, Liu, Fenyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074932/ https://www.ncbi.nlm.nih.gov/pubmed/24932966 http://dx.doi.org/10.3390/v6062376

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