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Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?

Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriu...

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Autores principales: Choi, Marcelo Roberto, Rukavina Mikusic, Natalia Lucía, Kouyoumdzian, Nicolás Martín, Kravetz, María Cecilia, Fernández, Belisario Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075025/
https://www.ncbi.nlm.nih.gov/pubmed/25013796
http://dx.doi.org/10.1155/2014/710781
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author Choi, Marcelo Roberto
Rukavina Mikusic, Natalia Lucía
Kouyoumdzian, Nicolás Martín
Kravetz, María Cecilia
Fernández, Belisario Enrique
author_facet Choi, Marcelo Roberto
Rukavina Mikusic, Natalia Lucía
Kouyoumdzian, Nicolás Martín
Kravetz, María Cecilia
Fernández, Belisario Enrique
author_sort Choi, Marcelo Roberto
collection PubMed
description Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, and receptor sensitization) which can be regulated by the atrial natriuretic peptide. At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the overinhibition of Na(+), K(+)-ATPase activity. In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and/or atrial natriuretic peptide, or as a result of impaired interaction between these two natriuretic systems. The aim of this review is to update and comment on the most recent evidences demonstrating how the renal dopaminergic system interacts with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways.
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spelling pubmed-40750252014-07-10 Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship? Choi, Marcelo Roberto Rukavina Mikusic, Natalia Lucía Kouyoumdzian, Nicolás Martín Kravetz, María Cecilia Fernández, Belisario Enrique Biomed Res Int Review Article Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, and receptor sensitization) which can be regulated by the atrial natriuretic peptide. At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the overinhibition of Na(+), K(+)-ATPase activity. In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and/or atrial natriuretic peptide, or as a result of impaired interaction between these two natriuretic systems. The aim of this review is to update and comment on the most recent evidences demonstrating how the renal dopaminergic system interacts with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways. Hindawi Publishing Corporation 2014 2014-06-12 /pmc/articles/PMC4075025/ /pubmed/25013796 http://dx.doi.org/10.1155/2014/710781 Text en Copyright © 2014 Marcelo Roberto Choi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Choi, Marcelo Roberto
Rukavina Mikusic, Natalia Lucía
Kouyoumdzian, Nicolás Martín
Kravetz, María Cecilia
Fernández, Belisario Enrique
Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?
title Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?
title_full Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?
title_fullStr Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?
title_full_unstemmed Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?
title_short Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?
title_sort atrial natriuretic peptide and renal dopaminergic system: a positive friendly relationship?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075025/
https://www.ncbi.nlm.nih.gov/pubmed/25013796
http://dx.doi.org/10.1155/2014/710781
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