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Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?
Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075025/ https://www.ncbi.nlm.nih.gov/pubmed/25013796 http://dx.doi.org/10.1155/2014/710781 |
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author | Choi, Marcelo Roberto Rukavina Mikusic, Natalia Lucía Kouyoumdzian, Nicolás Martín Kravetz, María Cecilia Fernández, Belisario Enrique |
author_facet | Choi, Marcelo Roberto Rukavina Mikusic, Natalia Lucía Kouyoumdzian, Nicolás Martín Kravetz, María Cecilia Fernández, Belisario Enrique |
author_sort | Choi, Marcelo Roberto |
collection | PubMed |
description | Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, and receptor sensitization) which can be regulated by the atrial natriuretic peptide. At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the overinhibition of Na(+), K(+)-ATPase activity. In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and/or atrial natriuretic peptide, or as a result of impaired interaction between these two natriuretic systems. The aim of this review is to update and comment on the most recent evidences demonstrating how the renal dopaminergic system interacts with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways. |
format | Online Article Text |
id | pubmed-4075025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40750252014-07-10 Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship? Choi, Marcelo Roberto Rukavina Mikusic, Natalia Lucía Kouyoumdzian, Nicolás Martín Kravetz, María Cecilia Fernández, Belisario Enrique Biomed Res Int Review Article Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, and receptor sensitization) which can be regulated by the atrial natriuretic peptide. At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the overinhibition of Na(+), K(+)-ATPase activity. In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and/or atrial natriuretic peptide, or as a result of impaired interaction between these two natriuretic systems. The aim of this review is to update and comment on the most recent evidences demonstrating how the renal dopaminergic system interacts with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways. Hindawi Publishing Corporation 2014 2014-06-12 /pmc/articles/PMC4075025/ /pubmed/25013796 http://dx.doi.org/10.1155/2014/710781 Text en Copyright © 2014 Marcelo Roberto Choi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Choi, Marcelo Roberto Rukavina Mikusic, Natalia Lucía Kouyoumdzian, Nicolás Martín Kravetz, María Cecilia Fernández, Belisario Enrique Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship? |
title | Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship? |
title_full | Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship? |
title_fullStr | Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship? |
title_full_unstemmed | Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship? |
title_short | Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship? |
title_sort | atrial natriuretic peptide and renal dopaminergic system: a positive friendly relationship? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075025/ https://www.ncbi.nlm.nih.gov/pubmed/25013796 http://dx.doi.org/10.1155/2014/710781 |
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