Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate

Bisphosphonate, a potent anti-resorptive agent, is generally accepted as a safe, effective, well tolerated treatment for postmenopausal osteoporosis. Atypical femoral fracture (AFF) and bisphosphonate related osteonecrosis of jaw (BRONJ) are the increasing morbidities in patients treated with long t...

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Autores principales: Won, Yougun, Lim, Joon-Ryul, Kim, Young-Hwan, Song, Hyung-keun, Yang, Kyu Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Bone and Mineral Research 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075270/
https://www.ncbi.nlm.nih.gov/pubmed/25025002
http://dx.doi.org/10.11005/jbm.2014.21.2.155
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author Won, Yougun
Lim, Joon-Ryul
Kim, Young-Hwan
Song, Hyung-keun
Yang, Kyu Hyun
author_facet Won, Yougun
Lim, Joon-Ryul
Kim, Young-Hwan
Song, Hyung-keun
Yang, Kyu Hyun
author_sort Won, Yougun
collection PubMed
description Bisphosphonate, a potent anti-resorptive agent, is generally accepted as a safe, effective, well tolerated treatment for postmenopausal osteoporosis. Atypical femoral fracture (AFF) and bisphosphonate related osteonecrosis of jaw (BRONJ) are the increasing morbidities in patients treated with long term bisphosphonate. Pathogenic mechanisms of AFF and BRONJ are not fully identified and not identical. We report a case of BRONJ followed by AFF and its nonunion in a 67-year-old woman patient receiving an oral bisphosphonate during 7 years for the treatment of osteoporosis.
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spelling pubmed-40752702014-07-14 Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate Won, Yougun Lim, Joon-Ryul Kim, Young-Hwan Song, Hyung-keun Yang, Kyu Hyun J Bone Metab Case Report Bisphosphonate, a potent anti-resorptive agent, is generally accepted as a safe, effective, well tolerated treatment for postmenopausal osteoporosis. Atypical femoral fracture (AFF) and bisphosphonate related osteonecrosis of jaw (BRONJ) are the increasing morbidities in patients treated with long term bisphosphonate. Pathogenic mechanisms of AFF and BRONJ are not fully identified and not identical. We report a case of BRONJ followed by AFF and its nonunion in a 67-year-old woman patient receiving an oral bisphosphonate during 7 years for the treatment of osteoporosis. The Korean Society for Bone and Mineral Research 2014-05 2014-05-31 /pmc/articles/PMC4075270/ /pubmed/25025002 http://dx.doi.org/10.11005/jbm.2014.21.2.155 Text en Copyright © 2014 The Korean Society for Bone and Mineral Research http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Won, Yougun
Lim, Joon-Ryul
Kim, Young-Hwan
Song, Hyung-keun
Yang, Kyu Hyun
Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate
title Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate
title_full Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate
title_fullStr Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate
title_full_unstemmed Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate
title_short Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate
title_sort atypical femoral fracture combined with osteonecrosis of jaw during osteoporosis treatment with bisphosphonate
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075270/
https://www.ncbi.nlm.nih.gov/pubmed/25025002
http://dx.doi.org/10.11005/jbm.2014.21.2.155
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