The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins

Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S-phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components and DNA repair proteins to prevent forks from ca...

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Detalles Bibliográficos
Autores principales: Tsang, Ellen, Miyabe, Izumi, Iraqui, Ismail, Zheng, Jiping, Lambert, Sarah A. E., Carr, Antony M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075360/
https://www.ncbi.nlm.nih.gov/pubmed/24806966
http://dx.doi.org/10.1242/jcs.152678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075360/
https://www.ncbi.nlm.nih.gov/pubmed/24806966
http://dx.doi.org/10.1242/jcs.152678

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