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The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins

Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S-phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components and DNA repair proteins to prevent forks from ca...

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Detalles Bibliográficos
Autores principales:	Tsang, Ellen, Miyabe, Izumi, Iraqui, Ismail, Zheng, Jiping, Lambert, Sarah A. E., Carr, Antony M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075360/ https://www.ncbi.nlm.nih.gov/pubmed/24806966 http://dx.doi.org/10.1242/jcs.152678

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